AI Article Synopsis
- Celiac disease (CD) is an autoimmune condition prevalent in Syria, marked by inflammation in the small intestine and various related symptoms, and linked to specific HLA-DQ genes.
- The study genotyped 49 children with CD and 58 healthy controls using the SSP-PCR technique, assessing the relative risks of different genotypes.
- Results showed that the DQB1*0201 allele was most common among patients, and carrying certain genotypes like DQ2.5/DQ8 significantly increased the risk of developing CD, highlighting the critical role of these alleles in Syrian children.
Article Abstract
Background: Celiac disease (CD) is a common autoimmune disease in Syria which manifesting with inflammation of the small intestine and with various extra intestinal symptoms. The disease is associated with human HLA-DQ genes encoding HLA-DQ2 and DQ8 proteins.
Methods: In this study, 49 children patients of CD and 58 healthy control samples were genotyped for HLA-DQ genes using SSP-PCR technique. Relative risks for different genotypes were also evaluated.
Results: The DQB1*0201 allele was the most common in the patients (77.6%) followed by DQB1*0302 allele (10.2%). The highest HLA-DQB risk for CD development was found in patients carriers a DQ2.5/DQ8 genotype (1/10), followed by the patients carriers DQ2.5/DQ2.5 (1/12).
Conclusion: The significant differences in the frequency of HLA-DQ2 and HLA-DQ8 in Syrian patients in compared with controls and relative risks predicted demonstrated the importance role of these alleles in the development of CD in Syrian children patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968552 | PMC |
| http://dx.doi.org/10.1186/s12876-018-0802-2 | DOI Listing |
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