Articular cartilage injury is common in clinical in recent years, due to the trauma or bone disease. There are many methods for the repair of articular cartilage injury currently, but each has its limitations. With the development of nanotechnology and bionic-technology, the scaffold plays an important role with tissue engineering technique in the repair of articular cartilage injury, in which the composite materials are the hot direction of the research and development, the ful application of nanotechnology and bionic-technology prospect in the future.
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Aging Dis
December 2024
Shandong Laboratory of Biomedical Materials Engineering, Success Bio-Tech Co., Ltd., Jinan, China.
Osteoarthritis (OA) is a common joint disease, which is mainly characterized by the degeneration of articular cartilage, inflammation of the synovial membrane of the joint, and changes in the surrounding bone tissue. With the increase of age and weight, the incidence of OA gradually increases, which seriously affects the quality of life of patients. The primary pharmacological treatments for OA include analgesics and non-steroidal anti-inflammatory drugs.
View Article and Find Full Text PDFBMC Musculoskelet Disord
January 2025
Department of Orthopedic Surgery, The 3rd Hospital of Hebei Medical University, Hebei, Shijiazhuang, 050051, P.R. China.
Background: It is known that open wedge high tibial osteotomy (OWHTO) may lead to progression of patellofemoral degeneration due to descent of the patellar height. However, the difference in patellofemoral joint (PFJ) loads with normal daily activity between uniplane and biplane osteotomies is unclear. The purpose of this study was to reveal the differences in PFJ biomechanics between uniplane and biplane OWHTO using finite element analysis (FEA).
View Article and Find Full Text PDFJ Orthop Surg Res
January 2025
Department of Center of Precision Medicine, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital of Wannan Medical College), Zheshan West Road, Wuhu, 241001, Anhui, China.
Background: There is currently no definitive treatment for osteoarthritis. We examined the therapeutic effects and underlying mechanisms of platelet-rich plasma (PRP) and adipose-derived mesenchymal stem cells (ADSCs), individually or in combination, in a rat model of anterior cruciate ligament-induced degenerative osteoarthritis (OA) of the knee. This study seeks to advance clinical approaches to OA treatment.
View Article and Find Full Text PDFSci Rep
January 2025
Guangzhou First People's Hospital, the Second Affiliated Hospital, School of Medicine, South China University of Technology; Guangzhou First People's Hospital, Guangzhou Medical University, 1 Panfu Road, Yuexiu District, Guangzhou, 510180, China.
Osteoarthritis (OA) is a multi-factorial degenerative joint disease with unclear pathogenesis. Conservative treatments, primarily aimed at pain relief, fail to halt disease progression. Metabolic syndrome has recently been implicated in OA pathogenesis, underscoring the need for novel therapeutic strategies.
View Article and Find Full Text PDFBone Res
January 2025
The Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, CAS Key Laboratory of Brain Connectome and Manipulation, the Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, China.
Osteoarthritis (OA) is a degenerative joint disease accompanied with the loss of cartilage and consequent nociceptive symptoms. Normal articular cartilage maintains at aneural state. Neuron guidance factor Semaphorin 3A (Sema3A) is a membrane-associated secreted protein with chemorepulsive properties for axons.
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