AI Article Synopsis
- The study focused on synthesizing and testing 17 novel thiosemicarbazones derived from (-)-camphene for their antiviral activity and cytotoxicity in VERO cells using REMA and MTT methods.
- Most of the compounds demonstrated strong inhibitory effects on the growth of HRv, with MIC values ranging from 3.9 to over 250 μg/mL.
- Adding new nitrogenous groups to (-)-camphene enhanced the antiviral activity of some compounds, with the best Selectivity Index (SI) values indicating potential for developing new antituberculosis drugs.
Article Abstract
In this work the aim of study was the synthesis and evaluation of anti- activity as well as the cytotoxicity in VERO cells of a series of 17 novel thiosemicarbazones derived from the natural monoterpene (-)-camphene by REMA and MTT methods. Overall, the majority of tested compounds exhibited considerable inhibitory effects on the growth of HRv, especially the derivatives , , , , , and . MIC values of 20 tested compounds ranged from 3.9 to > 250 μg/mL. It was found that when inserting new nitrogenous groups to the (-)-camphene increased the anti- activity of some compounds. The SI was calculated for all compounds that showed highly potent anti- activity and the best SI values were 21.36, 26.92 and 31.62 (, and ), and may be considered potential candidates for future antituberculosis drugs.
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| http://dx.doi.org/10.1080/14786419.2018.1478829 | DOI Listing |
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