[INCREASING EFFICACY OF PREGRAVIDAR PREPARATION IN MARRIED COUPLES SUFFERING OF INCREASED RISK OF PREGNANCY MISCARRIAGE.].

This study was aimed at revealing clinical and laboratory peculiarities in the health of married couples suffering of pregnancy miscarriage and the possibility of correcting this state by preconception therapy with reamberin, based on analysis of the results of observations and investigations for 196 married couples. At the first stage, we have studied the influence of provoking factors on the miscarriage during first trimester, including the presence and degree of chronic nonspe- cific intoxication. The patients were divided into groups: first (main) group including 40 couples, in which the pregnancy was complicated by the risk of pre- gnancy termination in the first trimester and second (comparison) group of 74 couples, in which abortion in the first trimester was followed by complex precon- ception therapy. The control group included 82 couples with normal course of pregnancy in the first trimester. At the second stage, we have studied the efficacy of including reamberin in the scheme of therapy. For this purpose, patients in the second (comparison) group were separated into subgroups. In subgroup I, 50 male patients received reamberin (i.v., dropwise, 400 mL per day at a rate of 60 - 70 drops/min, over 10 days), while 24 male patients of subgroup II were treated according to commonly accepted schemes (involving recommendations concerning regime and diet, psychological aid, and polyvitamins in prophylac- tic doses). Analysis of the obtained data revealed the presence of nonspecific intoxication in patients of the main group comparison groups, which was related to the increased level of intermediate metabolism products and osmotic state of plasma, and disorders in the hepatobiliary system as manifested by hyperbiliru- binemia, increased level of transaminases, urea, creatinine, etc. In addition, most patients also exhibited changes in spermograms, including astenozospermia (75.9 ? 7.9%) and teratozospermia (69 ? 8.6%) on the background of relative androgenous insufficiency, and bacterospermia in 26.7 ? 8.1% of patients from couples where the pregnancy of females was complicated by risk of miscarriage in the first trimester, and in 34.3 ? 5.8% of patients from couples receiving re- habilitation care upon abortion in the first trimester. The inclusion of reamberin in the scheme of complex preconception therapy of male in pairs with miscarri- age problems increased the efficacy of therapy. This was manifested by decrease in the parameters of intoxication (on the average by 21 % (d = 0.017), positive dynamics of the main indices of spermograms, and improvement of the general state, which led in turn to increased probability of the onset and maintenance of pregnancy.