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Advances in CRISPR-Cas technology and its applications: revolutionising precision medicine.
Front Genome Ed
December 2024
Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats-CRISPR-associated proteins) has undergone marked advancements since its discovery as an adaptive immune system in bacteria and archaea, emerged as a potent gene-editing tool after the successful engineering of its synthetic guide RNA (sgRNA) toward the targeting of specific DNA sequences with high accuracy. Besides its DNA editing ability, further-developed Cas variants can also edit the epigenome, rendering the CRISPR-Cas system a versatile tool for genome and epigenome manipulation and a pioneering force in precision medicine. This review explores the latest advancements in CRISPR-Cas technology and its therapeutic and biomedical applications, highlighting its transformative impact on precision medicine.
View Article and Find Full Text PDFCongenitally Missing Lateral Incisors: Prioritizing Space Closure Whenever Feasible.
Cureus
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Orthodontics and Dentofacial Orthopedics, Private Sector, Riyadh, SAU.
Congenital missing teeth are among the most prevalent dental malformations. Maxillary lateral incisors are particularly prone to agenesis, often missing bilaterally. This condition presented complex challenges for both patients and clinicians.
View Article and Find Full Text PDFEngineering Metabolic Flux for the Microbial Synthesis of Aromatic Compounds.
Metab Eng
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School of Biotechnology, Jiangnan University, Wuxi 214122, China. Electronic address:
Microbial cell factories have emerged as a sustainable alternative to traditional chemical synthesis and plant extraction methods for producing aromatic compounds. However, achieving economically viable production of these compounds in microbial systems remains a significant challenge. This review summarizes the latest advancements in metabolic flux regulation during the microbial production of aromatic compounds, providing an overview of its applications and practical outcomes.
View Article and Find Full Text PDFHormonal regulation and crosstalk during early endosperm and seed coat development.
Plant Reprod
December 2024
Max Planck Institute of Molecular Plant Physiology, Potsdam Science Park, Am Mühlenberg 1, 14476, Potsdam, Germany.
This review covers the latest developments on the regulation of early seed development by phytohormones. The development of seeds in flowering plants starts with the fertilization of the maternal gametes by two paternal sperm cells. This leads to the formation of two products, embryo and endosperm, which are surrounded by a tissue of maternal sporophytic origin, called the seed coat.
View Article and Find Full Text PDFMillets for a sustainable future.
J Exp Bot
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Molecular Systems Biology Lab (MOSYS), Department of Functional and Evolutionary Ecology, University of Vienna, Djerassiplatz 1, 1030 Vienna, Austria.
Our current agricultural system faces a perfect storm-climate change, burgeoning population, and unpredictable outbreaks like COVID-19 disrupt food production, particularly for vulnerable populations in developing countries. A paradigm shift in agriculture practices is needed to tackle these issues. One solution is the diversification of crop production.
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