Paediatric head computed tomography (CT) dose optimisation was carried out using three figure-of-merits (FOMs), based on tube voltage, current, noise, volumetric computed tomography dose index (CTDIvol) and contrast-to-noise ratio (CNR). FOM1: spatial resolution and total minimum contrast level (N) against CTDIvol; FOM2: noise against CTDIvol; FOM3: CNR against CTDIvol. Stage 1: Application of FOM1 and FOM2 on a Catphan without current modulation. Stage 2: CTDIvol and noise assessed on an anthropomorphic phantom with current modulation. Stage 3: All FOMs applied to Catphan images acquired with current modulation. Results indicated no single test case outperformed the current protocol (100 kVp, 200 mA) in all FOMs. Some test cases offered a reduction in dose at the cost of higher noise. The 120-kVp, 100-mA combination offered good compromise between dose and noise. Further investigation is required to determine whether this protocol could be added for procedures where higher noise is acceptable (e.g. craniosynostosis).
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http://dx.doi.org/10.1093/rpd/ncy078 | DOI Listing |
Exp Clin Endocrinol Diabetes
March 2025
Shaanxi Academy of Traditional Chinese Medicine, Xi'an, China.
Diabetic cardiomyopathy (DCM) is a serious complication in patients with diabetes, which still lacks adequate therapy. Ferroptosis has recently been emphasized as a main contributor to the development of DCM. Hence, the current study aimed to assess the effects of morin, a well-known phytochemical, on the DCM.
View Article and Find Full Text PDFInt J Radiat Oncol Biol Phys
March 2025
Department of Radiation Oncology, University of Michigan, Ann Arbor, MI. Electronic address:
Purpose/objective(s): Use of intensity-modulated radiation therapy (IMRT) versus three-dimensional conformal external beam radiation therapy (3D-CRT) for definitive chemoradiation therapy (CRT) in locally advanced non-small cell lung cancer (LA-NSCLC) has been associated with decreased late pneumonitis, decreased high dose to the heart (itself associated with improved overall survival), and improved patient quality of life. In a statewide radiation oncology quality consortium, we sought to evaluate the impact of IMRT versus 3D-CRT treatment technique on dosimetry and toxicity.
Materials/methods: From 2012 to 2022, 1746 LA-NSCLC patients meeting inclusion criteria underwent definitive RT (90% CRT) with either 3D-CRT (n=313) or IMRT (n=1433) and were enrolled in the [quality consortium] prospective, multicenter statewide initiative.
Bioorg Med Chem Lett
March 2025
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 310024, China. Electronic address:
Viral infectious diseases have been seriously affecting human life and health. SARS-CoV-2 was the pathogen that caused Coronavirus Disease 2019 (COVID-19), and the impact of COVID-19 is still existing. Enterovirus 71 (EV71) is the primary pathogen of hand, foot, and mouth disease (HFMD), and no effective direct-acting antiviral drugs targeting EV71 has been approved yet.
View Article and Find Full Text PDFPharmacol Res
March 2025
Biological Psychiatry Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Via Pilastroni 4, 25125 Brescia, Italy; Department of Pharmacological and Biomolecular Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy. Electronic address:
Schizophrenia is a severe and debilitating psychiatric disorder that profoundly impacts cognitive, emotional, and social functioning. Despite its devastating personal and societal toll, current treatments often provide only partial relief, underscoring the urgent need for innovative therapeutic strategies. This review explores emerging approaches that target the complex neurobiological underpinnings of schizophrenia, moving beyond traditional dopamine-centric models.
View Article and Find Full Text PDFHorm Metab Res
March 2025
Faculty of Pharmaceutical Sciences, Amrapali University, Haldwani, India.
The study explores the vital role of gut microbiota in regulating neurotransmitters and its subsequent effects on brain function and mental health. It aims to unravel the mechanisms by which microbial metabolites influence neurotransmitter synthesis and signaling. The ultimate goal is to identify potential therapeutic strategies targeting gut microbiota for the management and treatment of neurological disorders, such as depression, autism spectrum disorder (ASD), anxiety, and Parkinson's disease.
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