AI Article Synopsis
- Understanding the organization of neural circuits and how they connect is a complicated issue in neuroscience.
- Researchers, including Mao and colleagues, discovered that the timing of activation for a specific receptor called EphB2 influences whether certain dendrites will connect to potential axons.
- This finding provides significant insights into the underlying mechanisms of synapse formation in the brain.
Article Abstract
Understanding the mechanisms establishing the complex but precise pattern of connectivity characterizing neural circuits remains an immense challenge. In a recent issue of Neuron, Mao and colleagues (2018) provide new insights by showing that the activation kinetics of EphB2, a transmembrane receptor tyrosine kinase, control whether dendritic filopodia makes a synapse with candidate axons.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655511 | PMC |
| http://dx.doi.org/10.1016/j.devcel.2018.05.008 | DOI Listing |
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