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Analysis of microRNAs in familial Mediterranean fever. | LitMetric

AI Article Synopsis

  • This study investigates epigenetic modifications in Familial Mediterranean fever (FMF), which typically follows an autosomal recessive inheritance pattern.
  • Researchers analyzed the expression of microRNAs in ten severe FMF patients compared to ten healthy controls, excluding those with active inflammation.
  • They found significant differences in the expression of seven microRNAs, suggesting possible epigenetic changes that could help understand FMF better and serve as clinical biomarkers in the future.

Article Abstract

Objectives: Although Familial Mediterranean fever (FMF) is categorized as autosomal recessive, frequent exceptions to this model exist and therefore we aimed to search epigenetic modifications in this disease.

Methods: Ten M694V homozygous FMF patients (the most severe phenotype) were recruited for this study. Patients with inflammatory flare were excluded. Total RNA was extracted from peripheral blood, and microRNA expression profiled using NanoString nCounter technology. These patients were compared to 10 healthy age- and sex-matched controls.

Results: Seven hundred nighty-eight mature human miRNAs were probed, 103 of which had expression levels above the negative control probes. Seven miRNAs showed significant differences in expression in samples from FMF patients compared to healthy controls: four miRNAs were upregulated (miR-144-3p, miR-21-5p, miR-4454, and miR-451a), and three were downregulated (miR-107, let-7d-5p, and miR-148b-3p).

Conclusion: In this pilot study, we identified epigenetic modifications in clinically quiescent FMF patients. More studies are required for exploration of their contribution to FMF pathogenesis and their potential role as clinical biomarkers.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963758PMC
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197829PLOS

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