AI Article Synopsis
- Gastrointestinal diseases are on the rise in developed countries, highlighting the need for better human-specific models to study these conditions.
- Advances in pluripotent stem cells have enabled the creation of 'intestinal organoids', which are 3D cultures of intestinal cells that mimic the gut's structure and function.
- The review discusses current models of intestinal development and disease, identifies areas for improvement, and explores future applications in drug testing and potential new therapies.
Article Abstract
Gastrointestinal diseases are becoming increasingly prevalent in developed countries. Immortalized cells and animal models have delivered important but limited insight into the mechanisms that initiate and propagate these diseases. Human-specific models of intestinal development and disease are desperately needed that can recapitulate structure and function of the gut Advances in pluripotent stem cells and primary tissue culture techniques have made it possible to culture intestinal epithelial cells in three dimensions that self-assemble to form 'intestinal organoids'. These organoids allow for new, human-specific models that can be used to gain insight into gastrointestinal disease and potentially deliver new therapies to treat them. Here we review current models of intestinal development and disease, considering where improvements could be made and potential future applications in the fields of developmental modelling, drug/toxicity testing and therapeutic uses.This article is part of the theme issue 'Designer human tissue: coming to a lab near you'.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974440 | PMC |
| http://dx.doi.org/10.1098/rstb.2017.0217 | DOI Listing |
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