AI Article Synopsis
- The study investigated the link between serum high sensitivity C-reactive protein (hs-CRP) levels and sacroiliac joint inflammation in patients with undifferentiated spondyloarthritis (uSpA).
- Researchers analyzed data from 29 patients who underwent hs-CRP testing and skeletal imaging between 2007 and 2013.
- Findings showed a significant correlation between elevated hs-CRP levels and increased inflammation in the sacroiliac joint, suggesting that hs-CRP could be a useful marker for detecting joint inflammation in uSpA patients.
Article Abstract
Objective: Elevation of serum high sensitivity C-reactive protein (hs-CRP) level has been demonstrated as a risk factor for varying diseases, as well as a biomarker for predicting recovery after operation of lumber disc herniation. Our objective was to investigate the relationship between serum hs-CRP and sacroiliac (SI) joint inflammation in patients with undifferentiated spondyloarthritis (uSpA).
Methods: In this retrospective study, we enrolled patients with uSpA who underwent hs-CRP testing between January 2007 and September 2013. Serum hs-CRP was analyzed at our central laboratory. All enrolled patients underwent skeletal scintigraphic scan with quantitative sacroiliac measurement.
Results: A total of 29 patients were enrolled with mean age 32.27 years and female:male ratio of 6:23. Pearson's correlation coefficient showed a significant difference between hs-CRP in serum and SI/S ratio in uSpA, particularly the middle part of the sacroiliac joint, either right side or left side. The significantly high concentration of serum hs-CRP might indicate a systemic inflammatory response to flare-up of the SI joint and might be an indicator of SI inflammation in uSpA.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5960744 | PMC |
| http://dx.doi.org/10.1515/med-2018-0018 | DOI Listing |
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