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Molecular mechanisms of inverse agonism via κ-opioid receptor-G protein complexes.
Nat Chem Biol
January 2025
The Bridge Institute, Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USA.
Opioid receptors, a subfamily of G protein-coupled receptors (GPCRs), are key therapeutic targets. In the canonical GPCR activation model, agonist binding is required for receptor-G protein complex formation, while antagonists prevent G protein coupling. However, many GPCRs exhibit basal activity, allowing G protein association without an agonist.
View Article and Find Full Text PDFThe Antagonism Hypothesis: A New View on the Emergence of Consciousness.
Brain Behav
December 2024
School of Educational Science, Chongqing Normal University, Chongqing, China.
Purpose: The generation of consciousness poses a complex scientific challenge. Neuroscience and biological sciences have extensively studied this phenomenon, yielding numerous theories and hypotheses. However, to date, no reliable evidence has emerged to exclude any hypothesis conclusively, nor has any theory garnered unanimous agreement.
View Article and Find Full Text PDFSelective inhibition of T-type calcium channel preserves ischemic pre-conditioning mediated neuroprotection during cerebral ischemia reperfusion injury in diabetic mice.
Metab Brain Dis
November 2024
Charak School of Pharmacy, Chaudhary Charan Singh University, Meerut, Uttar Pradesh, India.
Ischemic preconditioning (IPC) provides ischemic tolerance and neuroprotection during cerebral ischemia reperfusion (CI/R) injury. Diabetes abolishes the beneficial effects of conditioning phenomenon during CI/R. The study investigates the role of T-type calcium ion channel in IPC mediated protection during diabetes mellitus.
View Article and Find Full Text PDFMusic therapy and psychotherapy - complementarity or antagonism in the treatment of patients with mental disorders.
Pol Merkur Lekarski
October 2024
MEDICAL UNIVERSITY OF LODZ, LODZ, POLAND.
Objective: Aim: The aim of the paper was to compare the principles of music therapy and psychotherapy, pointing out numerous similarities and differences between these two techniques.
Patients And Methods: Materials and Methods: Resistance is observed, as well as the phenomenon of transference and countertransference. In either method, the therapist is a covered therapeutic mirror for the patient/client.
Mirids secrete a TOPLESS targeting protein to enhance JA-mediated defense and gossypol accumulation for antagonizing cotton bollworms on cotton plants.
Mol Plant
November 2024
CAS Key Laboratory of Insect Developmental and Evolutionary Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, University of CAS, Chinese Academy of Sciences, Shanghai 200032, China. Electronic address:
Most coexisting insect species exhibit stunted growth compared to individual species on plants. This phenomenon reflects an interspecific antagonism drawing extensive attention, while the underlying mechanisms remain largely uncharacterized. Mirids (Apolygus lucorum) and cotton bollworms (Helicoverpa armigera) are two common cotton pests.
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