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Molecular and biological characterization of infectious full-length cDNA clones of two viruses in Paris yunnanensis, including a novel potyvirus.
Sci Rep
January 2025
State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan Agricultural University, Kunming, 650201, China.
Paris yunnanensis, also named as Rhizoma Paridis in the Chinese Pharmacopeia, is a perennial Chinese medicinal herb commonly grown in Southwest China. However, several viruses have been found infecting this plant in recent years. Using high-throughput sequencing (HTS) and Sanger sequencing, this study obtained the complete genome sequences of three capillovirus isolates and one potyvirus isolate.
View Article and Find Full Text PDFMolecular characterization of non- yeast communities isolated from trees.
Curr Med Mycol
March 2024
Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Background And Purpose: Plants are crucial habitats for fungus communities as they provide an appropriate physical environment for the growth and reproduction of the yeast microbiome. Varieties of pathogenic and non-pathogenic yeast could be found in trees. Although species are the most common pathogenic yeasts associated with trees, other yeasts also grow on trees and are critical to human health.
View Article and Find Full Text PDFModified Zuo Gui Wan Ameliorates Ovariectomy-Induced Osteoporosis in Rats by Regulating the SCFA-GPR41-p38MAPK Signaling Pathway.
Drug Des Devel Ther
January 2025
Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, People's Republic of China.
Article Synopsis
- MZGW (Modified Zuo Gui Wan) combines traditional herbal treatment and red yeast rice, showing promise in treating osteoporosis (OP) through its effects on osteoclasts.
- Research utilized both in vivo (OVX rat model) and in vitro (RANKL-induced osteoclasts) experiments to understand MZGW's mechanisms, particularly focusing on the SCFA-GPR41-p38MAPK signaling pathway.
- Results indicated that the high-dose MZGW improved bone microstructure and inhibited osteoclast activity by changing gut flora metabolism and effectively regulating specific signaling pathways.
[Antifungal immunity in patients with chronic rhinosinusitis with nasal polyps].
Vestn Otorinolaringol
December 2024
Bashkir State Medical University, Ufa, Russia.
Objective: To evaluate the characteristics of antifungal immunity in patients with bilateral chronic rhinosinusitis with nasal polyps.
Material And Methods: The study included 74 patients with bilateral chronic rhinosinusitis with nasal polyps and a control group consisting of 30 almost healthy individuals. All patients underwent surgery and were divided into two groups: Group I - with liquid secretion (=39), Group II - with thick secretion in the paranasal sinuses (=35).
The regulatory effect of chitooligosaccharides on islet inflammation in T2D individuals after islet cell transplantation: the mechanism behind abundance and macrophage polarization.
Gut Microbes
December 2025
State Key Laboratory of Bioreactor Engineering, School of Biotechnology, East China University of Science and Technology, Shanghai, China.
Islet cell transplantation (ICT) represents a promising therapeutic approach for addressing diabetes mellitus. However, the islet inflammation during transplantation significantly reduces the surgical outcome rate, which is related to the polarization of macrophages. Chitooligosaccharides (COS) was previously reported which could modulate the immune system, alleviate inflammation, regulate gut microecology, and repair the intestinal barrier.
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