Practice of personalized primary prevention of lifestyle diseases: associated problems and issues in Japan.

This article explores the current situation of personalized primary prevention of lifestyle diseases based on individuals' genome information in Japan. The Japanese healthcare system and regulatory framework of genetic testing have been reviewed because they relate to the issue. From our perspective, clinics and health check-up centers in Japan are appropriate centers for implementing measures for primary prevention of lifestyle diseases. For example, we researched a predictive genetic testing program for diabetic complications and metabolic syndrome. Based on our interviews with physicians and experts, we identified the following factors that are critical to the effective use of genetic testing for primary prevention of lifestyle diseases: an institutional framework for evaluating the credibility of predictive genetic testing; psychological effects (both positive and negative) of predictive genetic testing; and education of physicians and other health professionals in lifestyle disease genetics and effective communication with patients.