AI Article Synopsis
- The study evaluated the levels of estrogen (ER) and progesterone (PR) receptors in the endometrial tissue of infertile women compared to controls and examined their relationship with CD8+ receptors.
- Women with unexplained infertility showed significantly lower levels of ER and PR in both epithelial and stromal cells compared to the control group, indicating potential issues with endometrial function.
- The research found no significant correlation between CD8+ receptor positivity and the levels of ER and PR, suggesting that inflammation or immune response may not directly impact estrogen and progesterone receptor levels in these cases.
Article Abstract
Objective: The present study aimed to investigate the changes of endometrial progesterone and estrogen receptors in luteal phase biopsy specimens of infertile women and find a correlation, if any, between these and CD8+ receptors in the same.
Methods: The study was conducted on luteal phase endometrial biopsy specimens of 30 women of unexplained infertility and 15 age matched controls. Paraffin sections were first H & E stained. A standardized immunohistochemical protocol was then used to localize the estrogen, progesterone and CD8+ receptors in these samples that were expressed as percentage positivity. Unpaired T test was applied between the controls and cases both for epithelial and stromal cells. The data was also analyzed for correlation in cases for the positivity of CD8+ Cells with that of ER and PR.
Results: The positivity of estrogen receptors (ER) in stromal cells was significantly lower (p<0.001) in the infertile women when compared to controls and in both the epithelial and stromal cells for progesterone receptors (p<0.001). The results were non significant for CD8+ cells (p=0.19) and also showed no significant correlation in the positivity of CD8+ cells with that of ER and PR.
Conclusions: The development of molecular probe like ER and PR positivity in endometrial epithelial and stromal cells allows a new approach to be made to the characterization of normal and defective endometrial function.
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| http://dx.doi.org/10.1016/j.jogoh.2018.05.006 | DOI Listing |
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