Two rare C sesquiterpene lactone dimers, vlasouliolides J-K (1-2), together with three C sesquiterpene dimers, vlasoulioliones A-C (3-5), were isolated from Vladimiria souliei. Their chemical structures were elucidated by NMR and MS spectroscopic data. Among them, compounds 1, 3 and 5 were unambiguously established by Cu-Kα X-ray crystallographic analysis. Furthermore, compound 1 showed prominent neuroprotective effects against glutamate-induced neurotoxicity in PC-12 cells, with EC value of 2.11 ± 0.35 μM. And the leakage of LDH from glutamate-induced PC-12 was significantly reduced by compound 1 at concentration of 10 μM.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.fitote.2018.05.022 | DOI Listing |
Publication Analysis
Top Keywords
vladimiria souliei
8
rare dimeric
4
dimeric sesquiterpenes
4
sesquiterpenes exhibiting
4
exhibiting potential
4
potential neuroprotection
4
neuroprotection activity
4
activity vladimiria
4
souliei rare
4
rare sesquiterpene
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!