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Beyond Classic Leprosy: Exploring Atypical Manifestations and Their Diagnostic Challenges.
Cureus
December 2024
Department of Dermatology, Venereology and Leprosy, Great Eastern Medical School & Hospital, Srikakulam, IND.
Leprosy, or Hansen's disease, is an ancient infectious disease characterized by varied clinical presentations influenced by the host's immune response. This study aimed to explore the atypical manifestations of Hansen's disease in a cohort of 15 biopsy-confirmed patients admitted to the Department of Dermatology, Venereology & Leprosy at a tertiary care center in Andhra Pradesh, India. There were 14 male patients and one female patient, with a mean age of 42.
View Article and Find Full Text PDFSuccessful Treatment of Refractory Ulcerative Colitis With 5-Aminosalicylic Acid Intolerance and Biologic Therapy Resistance Using Combined Granulocyte and Monocyte Adsorptive Apheresis.
Cureus
January 2025
Department of Gastroenterology, Tsuchiya General Hospital, Hiroshima, JPN.
We report the case of a 37-year-old male patient diagnosed with moderate left-sided ulcerative colitis (UC). Initial therapy with 5-aminosalicylic acid (5-ASA) was terminated within days due to exacerbation of symptoms, leading to a diagnosis of 5-ASA intolerance. Although induction of remission was achieved with prednisolone, the patient developed steroid dependency.
View Article and Find Full Text PDFComparison of different decellularization methods for human anterior lens capsules.
BMC Ophthalmol
January 2025
Eye Institute, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
Background: Human anterior lens capsules (ALCs) have great potential in the treatment of multiple eye diseases, including corneal ulcers, glaucoma, age-related macular degeneration and macular holes. ALCs are also regarded as promising scaffolds for various ocular cells. Here, we investigated different decellularization methods for removing lens epithelial cells (LECs) that adhered to ALCs.
View Article and Find Full Text PDFCarotid artery atherosclerotic stenosis is an important annual cause of stroke in the United States. Moreover, the incidence of carotid artery stenosis is significantly increasing due to the widespread popularity of high fat and high salt diets, sedentary lifestyles, and the increasing age of the population. Of major importance to cardiovascular specialists is the fact that individuals with atherosclerotic carotid artery stenosis can have a prevalence of atherosclerotic coronary artery disease as high as 50 to 75%.
View Article and Find Full Text PDFPerianal mass as the debut of metastatic pulmonary neoplasia.
Rev Esp Enferm Dig
January 2025
General and Digestive Surgery. Coloproctology Unit, Hospital Universitario Donostia.
A 56-year-old male smoker presented to the Emergency Department with a painful mass in the left ischiorectal fossa, which had been present for 2 months without any other symptoms. On examination, a hard, violet-colored mass was observed, with an ulcerated central area. Blood tests were normal, and the abdominal-pelvic CT scan showed multiple hypervascular intra-abdominal masses and soft tissue lesions.
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