A new diterpene, cassipouryl hexadecanoate (), in addition to the cassipourol () and four terpenes () were isolated from the twigs and leaves of (Blume) de Laub. The structures of the two monocyclic diterpenes (, ), were elucidated on the basic of 1D and 2D NMR spectroscopic data and compared with the literature. These two monocyclic diterpenes (, ) were tested for their anti-proliferative activity on acute myeloid leukemia (OCI-AML) cells. The results showed that had significantly anti-proliferative activity whereas was weakly active.
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http://dx.doi.org/10.1080/14786419.2018.1477149 | DOI Listing |
Molecules
June 2024
College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
To better assess the practical value and avoid potential risks of the traditionally medicinal and edible basidiomycete , which may arise from undescribed metabolites, a combination of elicitors was introduced for the first time to discover products from cryptic and low-expressed gene clusters under laboratory cultivation. Treating NJFU21 with the combination of five elicitors led to the upregulated production of a class of unusual linear diterpene-derived variants, including eleven new ones (-), along with three known ones (-). The structures and stereochemistry were determined by 1D and 2D NMR, HRESIMS, ECD, OR and VCD calculations.
View Article and Find Full Text PDFNaunyn Schmiedebergs Arch Pharmacol
July 2024
Department of Biotechnology, Alagappa University, Karaikudi, 630 003, Tamil Nadu, India.
This study explored the potential of poly-(lactic-co-glycolic) acid (PLGA) nanoparticles to enhance the effectiveness of anticancer treatments through combination therapy with phytol and α-bisabolol. The encapsulation efficiency of the nanoparticles was investigated, highlighting the role of ionic interactions between the drugs and the polymer. Characterization of PLGA-Phy+Bis nanoparticles was carried out using DLS with zeta potential and HR-TEM for size determination.
View Article and Find Full Text PDFBiotechnol J
January 2024
The Key Laboratory of Industrial Biotechnology, School of Biotechnology, Ministry of Education, Jiangnan University, Wuxi, China.
Cembratriene-ol is a good biodegradable biopesticide ingredient with future potential applications in the field of sustainable agriculture. Cembratriene-ol is a monocyclic diterpenoid compound that is synthesized only in the trichome gland of Nicotiana plants. In this study, geranylgeranyl diphosphate synthase gene ggpps from Taxus canadensis and cbts*Δp were heterologously expressed in Saccharomyces cerevisiae W303-1A to successfully synthesize cembratriene-ol.
View Article and Find Full Text PDFJ Nat Prod
February 2023
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
Sarcotragusolides A-D (-), four new butenolide sesterterpenes featuring a rare methyl-transferred 6/6/6-tricyclic fused ring system with a butyrolactone moiety, and echinohalimane B (), an unprecedented monocyclic diterpenoid featuring a 2,7-ring-opened halimane-type skeleton, were isolated from the sponge sp. A γ-hydroxybutenolide sesterterpene derivative (), a new scalarane sesterterpene (), a new subersin-type diterpenoid (), and two known terpenoids were also isolated and identified. The discovery of sarcotragusolides C and D ( and ) with an unprecedented inversion of configuration implied a distinct biosynthetic pathway.
View Article and Find Full Text PDFToxicol Lett
January 2023
Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 1-1-1, Tsushimanaka, Kita-ku, Okayama 700-8530, Japan.
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