AI Article Synopsis
- A dual drug delivery system has been created using mesoporous silica nanoparticles (MSNs) to deliver doxorubicin (DOX) and camptothecin (CPT) in a pH-sensitive manner.
- DOX is attached to the surface of the MSNs with a linker that responds to acidity, while CPT is stored within the nanopores of the silica.
- At normal pH, drug release is minimal, but in acidic environments, like those found in tumors, there is a rapid release of DOX and a slower release of CPT, making it effective for combination therapy.
Article Abstract
A dual doxorubicin/camptothecin (DOX/CPT) pH-triggered drug delivery mesoporous silica nanoparticle (MSN)-based nano-vehicle has been prepared. In this drug-delivery system (DDS), CPT is loaded inside the pores of the MSNs, while DOX is covalently attached to the surface of an aldehyde-functionalized MSN through a dihydrazide-polyethylene glycol chain. Thus, DOX and the linker act as pH-sensitive gatekeeper. The system is versatile and easy to assemble, not requiring the chemical modification of the drugs. While at physiological conditions the release of the drugs is negligible, at acidic pH a burst release of DOX and a gradual release of CPT take place. In vitro cytotoxicity tests have demonstrated that this DDS can deliver efficiently DOX and CPT for combination therapy.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058477 | PMC |
| http://dx.doi.org/10.1080/10717544.2018.1472678 | DOI Listing |
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Article Synopsis
- A dual drug delivery system has been created using mesoporous silica nanoparticles (MSNs) to deliver doxorubicin (DOX) and camptothecin (CPT) in a pH-sensitive manner.
- DOX is attached to the surface of the MSNs with a linker that responds to acidity, while CPT is stored within the nanopores of the silica.
- At normal pH, drug release is minimal, but in acidic environments, like those found in tumors, there is a rapid release of DOX and a slower release of CPT, making it effective for combination therapy.
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