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The RAB32 p.Ser71Arg Variant in Parkinsonisms: Insights from a Large Italian Cohort.
Mov Disord
December 2024
Department of Biomedical Sciences, Humanitas University, Milan, Italy.
Background And Objective: Recently, RAB32 has been identified as possibly linked to Parkinson's disease. We studied the prevalence and clinical correlates of the p.Ser71Arg variant in the RAB32 gene in a large case series of Italian patients with Parkinson's disease or atypical parkinsonism.
View Article and Find Full Text PDFAcute Appendicitis Due to Enterobius vermicularis Infestation: A Case Report.
Cureus
December 2024
Department of General Surgery, East Kent Hospitals University NHS Foundation Trust, Queen Elizabeth The Queen Mother Hospital, Margate, GBR.
Acute appendicitis is the most frequent abdominal surgical emergency worldwide. While luminal obstruction due to fecaliths and lymphoid hyperplasia is a common cause, parasitic infections are a rare but significant contributor. , the most common helminthic infection in developed countries, can trigger appendiceal inflammation through a mechanical obstruction or immune response.
View Article and Find Full Text PDFPersistent Knee Monoarthritis as a Lyme Disease Presentation: A Diagnostic Challenge - Case Report.
Rev Bras Ortop (Sao Paulo)
November 2024
Hospital Ortopédico de Sant'Ana, Parede, Portugal.
There are several differential diagnoses for knee monoarthritis. We report a patient with recurrent episodes of knee effusion, in which the non-specific clinical condition implied several diagnostic hypotheses, therapeutic inaccuracies, and a delay in implementing adequate treatment. For more than 2 years, the patient underwent different Orthopedics and Rheumatology visits.
View Article and Find Full Text PDFCelecoxib paradoxically induces COX-2 expression and astrocyte activation through the ERK/JNK/AP-1 signaling pathway in the cerebral cortex of rats.
Neurochem Int
December 2024
Master and PhD Programs in Pharmacology and Toxicology, School of Medicine, Tzu Chi University, Hualien, Taiwan 970; Department of Pharmacology, School of Medicine, Tzu Chi University, Hualien, Taiwan 970. Electronic address:
Previous studies have shown that celecoxib or NSAID may paradoxically induce cyclooxygenase-2 (COX-2) expression and trigger inflammation-like responses in airway smooth muscle cells and renal mesangial cells. Despite the extensive research on celecoxib, its atypical biological effect on the induction of COX-2 in astroglial cells within the central nervous system (CNS) remains unexplored. In the present study, we investigated the impact of celecoxib on COX-2 and Glial Fibrillary Acidic Protein (GFAP) expression and explored the mechanisms underlying celecoxib-regulated COX-2 expression in cortical astrocytes of rats.
View Article and Find Full Text PDFMechanistic insights into Quetiapine's Protective effects on cognitive function and synaptic plasticity in epileptic rats.
Brain Res
December 2024
Ningxia Clinical Research Institute, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan, Ningxia, PR China.
The study aimed to examine the effects of Quetiapine, an atypical antipsychotic medication with purported neuroprotective qualities, on cognitive function and synaptic plasticity in epileptic rats. This investigation also sought to elucidate the mechanisms by which quetiapine influences the activity of the cyclic adenylate response element binding protein (CREB)/brain-derived neurotrophic factor (BDNF) signaling pathway and metallomatrix proteinase-9 (MMP9) expression in the context of epilepsy. The epileptic model was induced in rats through the administration of pilocarpine, with normal rats serving as the control group.
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