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Clinical Implication of MicroRNAs in Molecular Pathology: An Update for 2018. | LitMetric

Clinical Implication of MicroRNAs in Molecular Pathology: An Update for 2018.

Clin Lab Med

Department of Pathology, Wayne State University, School of Medicine, 540 East Canfield Street, Detroit, MI 48201, USA; Pathology Laboratories, Michigan Surgical Hospital, 21230 Dequindre Road, Warren, MI 48091, USA.

Published: June 2018

AI Article Synopsis

Article Abstract

MicroRNAs (miRNAs) are poised to provide diagnostic, prognostic, and therapeutic targets for several diseases including malignancies for precision medicine applications. The miRNAs have immense potential in the clinical arena because they can be detected in the blood, serum, tissues (fresh and formalin-fixed paraffin-embedded), and fine-needle aspirate specimens. The most attractive feature of miRNA-based therapy is that a single miRNA could be useful for targeting multiple genes that are deregulated in cancers, which can be further investigated through systems biology and network analysis that may provide cancer-specific personalized therapy.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cll.2018.02.003DOI Listing

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