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Engineering dimer mutants of human geranylgeranyl pyrophosphate synthase.
PLoS One
January 2025
Department of Biochemistry, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada.
Geranylgeranyl pyrophosphate synthase (GGPPS), a key enzyme in protein prenylation, plays a critical role in cellular signal transduction and is a promising target for cancer therapy. However, the enzyme's native hexameric quaternary structure presents challenges for crystallographic studies. The primary objective of this study was to engineer dimeric forms of human GGPPS to facilitate high-resolution crystallographic analysis of its ligand binding interactions.
View Article and Find Full Text PDFVestibular stimulation and space-time interaction affect the perception of time during whole-body rotations.
PLoS One
January 2025
COMETE U1075, Inserm, CYCERON, Université de Caen Normandie, Caen, France.
Among the factors, such as emotions, that distort time perception, vestibular stimulation causes a contraction in subjective time. Unlike emotions, the intensity of vestibular stimulation can be easily and precisely modified, making it possible to study the quantitative relationship between stimulation and its effect on time perception. We hypothesized that the contraction of subjective time would increase with the vestibular stimulation magnitude.
View Article and Find Full Text PDFA noncanonical-GPRC5A signaling regulates keratinocyte adhesion and migration by nuclear translocation.
FASEB J
January 2025
Laboratory of Tissue Biology and Therapeutic Engineering, UMR5305 CNRS, University Lyon 1, Lyon Cedex 07, France.
G-Protein Coupled Receptor, Class C, Group 5, Member A (GPRC5A) has been extensively studied in lung and various epithelial cancers. Nevertheless, its role in the skin remains to be elucidated. In this study, we sought to investigate the function of this receptor in skin biology.
View Article and Find Full Text PDFDual Activation Modes Enable Bifunctional Catalysis of Aldol Reactions by Flexible Dihydrazides.
J Am Chem Soc
January 2025
Department of Chemistry, University of Wisconsin─Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States.
Hydrazides are known to catalyze reactions of α,β-unsaturated aldehydes via transient iminium formation. The iminium intermediate displays enhanced electrophilicity, which facilitates conjugate additions and cycloadditions. We observed that a hydrazide embedded in a seven-membered ring catalyzes homoaldol condensation of a simple aldehyde in a process that displays an approximate second-order dependence on the hydrazide.
View Article and Find Full Text PDFMyristoylated Eepd1 Enhances Lipolysis and Thermogenesis through PKA Activation to Combat Obesity.
Nat Commun
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Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Middle-aged obesity, characterized by excessive fat accumulation and systemic energy imbalance, often precedes various health complications. Recent research has unveiled a surprising link between DNA damage response and energy metabolism. Here, we explore the role of Eepd1, a DNA repair enzyme, in regulating adipose tissue function and obesity onset.
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