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Maternal Western Diet Programmes Bile Acid Dysregulation and Hepatic Fibrosis in Fetal and Juvenile Macaques.
Liver Int
February 2025
Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Background And Aims: Maternal obesity increases the risk of the paediatric form of metabolic dysfunction-associated steatotic liver disease (MASLD), affecting up to 30% of youth, but the developmental origins remain poorly understood.
Methods: Using a Japanese macaque model, we investigated the impact of maternal Western-style diet (mWSD) or chow diet followed by postweaning WSD (pwWSD) or chow diet focusing on bile acid (BA) homeostasis and hepatic fibrosis in livers from third-trimester fetuses and 3-year-old juvenile offspring.
Results: Juveniles exposed to mWSD had increased hepatic collagen I/III content and stellate cell activation in portal regions.
Triglyceride-glucose index in predicting the risk of new-onset diabetes in the general population aged 45 years and older: a national prospective cohort study.
BMC Endocr Disord
January 2025
Department of Endocrinology, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, 110033, China.
Objective: Insulin resistance (IR) is often present in diabetes, which imposes a heavy burden on the prevention and treatment of diabetes. Triglyceride glucose index (TyG) is simple, reliable and reproducible in detecting IR, and has great advantages in predicting the risk of diabetes. The aim of this study was to analyze the potential association between TyG and the risk of diabetes in Chinese middle-aged and older adults using a prospective cohort study design.
View Article and Find Full Text PDFAssociation between informal caregiving and changes in cardiovascular-related health behaviors among middle-aged and older adults in Japan: A 15-year panel survey.
J Epidemiol
January 2025
Department of Health Services Research, Institute of Medicine, University of Tsukuba.
BackgroundStudies have shown that informal caregiving is associated with an increased risk of cardiovascular diseases. However, there is limited evidence on the mechanisms involved. To fill this knowledge gap, we investigated the association of informal caregiving with changes in health-related behaviors.
View Article and Find Full Text PDFClinical Features Evaluation of Myopic Fundus tessellation from OCTA and MfERG.
Photodiagnosis Photodyn Ther
January 2025
Ningbo Eye Hospital, Wenzhou Medical University, Ningbo, Zhejiang, 315000, P.R. China. Electronic address:
Purpose: To evaluate the differences in fundus tessellation among various severities using multifocal visual electrophysiology (MfERG) and optical coherence tomography angiography (OCTA) for clinical grading and treatment.
Methods: This study included 52 patients totaling 87 eyes. The Early Treatment Diabetic Retinopathy Study (ETDRS) grid division method was utilized to assess Grade of fundus tessellation.
Vitamin D augments insulin secretion via calcium influx and upregulation of voltage calcium channels: Findings from INS-1 cells and human islets.
Mol Cell Endocrinol
January 2025
Research Institute of Medical and Health Sciences, University of Sharjah, P.O. Box 27272, Sharjah, United Arab Emirates; College of Medicine, University of Sharjah, P.O. Box 27272, Sharjah United Arab Emirates.
Vitamin D (VD) has been implicated in regulating insulin secretion and pancreatic β-cell function. Yet, the underlying molecular mechanism of VD in glucose homeostasis is not fully understood. This study investigates the effect of VD in regulating insulin secretion and pancreatic β-cell function.
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