AI Article Synopsis
- The Ebola virus (EBOV) is a highly contagious and lethal virus with a significant outbreak in West Africa in 2014, resulting in over 11,000 deaths, and currently lacks licensed vaccines.
- Research indicates that CD4 and CD8 T-cell responses, particularly cytotoxic T-lymphocyte (CTL) responses, are crucial for immunity against EBOV.
- The study identified ten potential HLA-A11-restricted CTL epitopes in the EBOV-nucleoprotein, with five (GR-9, VR-9, EK-9, PK-9, and RK-9) showing promise in producing effective CTL responses in transgenic mice, paving the way for future epitope vaccine development
Article Abstract
The Ebola virus (EBOV) is a very contagious virus that is highly fatal in humans and animals. The largest epidemic was in West Africa in 2014, in which over 11,000 people died. However, to date, there are no licensed vaccines against it. Studies show that CD4 and CD8 T-cell responses, especially cytotoxic T-lymphocyte (CTL) responses, play key roles in protecting individuals from EBOV infection. Since HLA-restricted epitope vaccines are likely to be effective and safe immunization strategies for infectious diseases, the present study screened for CTL epitopes in the EBOV-nucleoprotein that are restricted by HLA-A11 (a common allele in Chinese people). Predictive computer analysis of the amino-acid sequence of EBOV-nucleoprotein identified ten putative HLA-A11-restricted epitopes. ELISPOT assay of immunized HLA-A11/DR1 transgenic mice showed that five (GR-9, VR-9, EK-9, PK-9, and RK-9) induced effective CTL responses. Additional epitope analyses will aid the design of epitope vaccines against EBOV.
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| http://dx.doi.org/10.1016/j.micinf.2018.04.005 | DOI Listing |
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