The aim of this study is to investigate the distribution of IL-10, CD14 and CD68 in the tumor microenvironment of LSCC with the clinicopathologic factors. We detected the expressions of IL-10, CD14 and CD68 in 46 primary LSCC tumor tissues by immunohistochemistry staining and explore the relationship between them and clinicopathologic factors. We found that the expressions of IL-10, CD14 and CD68 were significantly correlated with clinical stage and T stage (<0.01). IL-10 and CD14 were correlated with lymph node metastasis (<0.01), and CD68 was correlated with pathological differentiation (<0.05). There is a positive correlation trend between the expression of IL-10 and CD14 (<0.01). We confirm that the high level expressions of IL-10, monocytes and TAMs contribute to the tumor development of LSCC and there is a positive correlation between the expression of IL-10 and monocytes.
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| http://dx.doi.org/10.13201/j.issn.1001-1781.2017.11.006 | DOI Listing |
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