The tau fibrillar structures from the brain of an Alzheimer's patient have a core with a C-shaped motif of the third and fourth repeat domains (R3-R4). Our simulations indicated that the C-shaped motif is only stable for R3-R4, while R1-R2 tends to be linear in shape. These two structural motifs appear in the most stable K18 protofilament. Heparin can further stabilize the C-shaped R3-R4 motif, but not other repeats.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986281 | PMC |
| http://dx.doi.org/10.1039/c8cc01263f | DOI Listing |
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