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http://dx.doi.org/10.1084/jem.2006183905142018c | DOI Listing |
Int J Mol Sci
December 2024
Department of Pharmacology, National Institute of Cardiology Ignacio Chávez, Juan Badiano No. 1, Col. Seccion XVI, Tlalpan, Mexico City 14080, Mexico.
Chronic hyperglycemia results in morphological and functional alterations of the kidney and microvascular damage, leading to diabetic nephropathy (DN). Since DN progresses to irreversible renal damage, it is important to elucidate a pharmacological strategy aimed for treating DN in the early stage. Here, we used the type 2 diabetic rat model to induce DN and show a nephroprotective effect following the stimulation of PPAR-α, which stabilized renal tight junction components claudin-2, claudin-5, and claudin-16.
View Article and Find Full Text PDFNat Chem Biol
November 2024
Department of Bioengineering, University of California, Berkeley, CA, USA.
Newborn (Clarksville)
March 2024
Global Newborn Society, Clarksville Maryland, United States of America.
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