Fluorescent spirolactone derivatives are obtained by coupling 3-carboxylic coumarins to a spirolactone bearing a 3-hydroxypropyl chain in the 7 alpha position. The two esters prepared by this method are highly fluorescent (emission 383 and 408 nm).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0039-128x(88)90045-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dyes-encapsulated metal-organic cage as fluorescence sensor array for the auxiliary differential diagnosis of MCD and FSGS in early renal disorders.
Biosens Bioelectron
March 2025
Center of Advanced Analysis and Gene Sequencing, Key Laboratory of Molecular Sensing and Harmful Substances Detection Technology, Zhengzhou University, Kexue Avenue 100, Zhengzhou, Henan, 450001, PR China.
Both minimal change disease (MCD) and focal segmental glomerular sclerosis (FSGS) are the pathological types of primary nephrotic syndrome (PNS) and cannot be readily distinguished owing to their highly similar clinical presentations. Currently, methods for clinical MCD and FSGS diagnosis still rely on invasive renal biopsy which impede rapid and accurate diagnosis for timely treatment management. In this study, a novel diagnostic strategy by introducing the dyes with spironolactone structure into the metal-organic cage to construct three dye@MOCs composites has been developed and employed as fluorescence sensor array for assisting in the auxiliary differential diagnosis of MCD and FSGS based on the distinguishable biothiols in urine.
View Article and Find Full Text PDFApplication of Fluorescent Composite Materials as a Sustained Release System in Treatment of Polycystic Ovary Syndrome.
J Fluoresc
October 2024
Reproductive Medicine Center, Zhongshan Hospital Affiliated to Fudan University, Shanghai, China.
Polycystic ovary syndrome (PCOS) is a multifactorial disease characterized by oxidative stress and follicular dysfunction, leading to menstrual irregularities, hyperandrogenism, and infertility. Traditional drug delivery methods often result in drug loss and side effects on normal tissues. To address these issues, we synthesized two novel Co(II)-containing coordination polymers (CPs), {[Co(L)(HO)]·2HO}n (1) and {[Co(L)(HO)]·1.
View Article and Find Full Text PDFPrenatal exposure to the mineralocorticoid receptor antagonist spironolactone disrupts hippocampal area CA2 connectivity and alters behavior in mice.
Neuropsychopharmacology
December 2024
Neurobiology Laboratory, National Institute of Environmental Health Sciences, Division of Intramural Research, National Institute of Health, Research Triangle Park, NC, 27709, USA.
In the brain, the hippocampus is enriched with mineralocorticoid receptors (MR; Nr3c2), a ligand-dependent transcription factor stimulated by the stress hormone corticosterone in rodents. Recently, we discovered that MR is required for the acquisition and maintenance of many features of mouse area CA2 neurons. Notably, we observed that immunofluorescence for the vesicular glutamate transporter 2 (vGluT2), likely representing afferents from the supramammillary nucleus (SuM), was disrupted in the embryonic, but not postnatal, MR knockout mouse CA2.
View Article and Find Full Text PDFNovel detoxifier of spironolactone against triptolide-induced hepatotoxicity through inhibition of RPB1 degradation.
J Ethnopharmacol
January 2025
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address:
Ethnopharmacological Relevance: Triptolide is a major bioactive and toxic ingredient isolated from the traditional Chinese herb Tripterygium wilfordii (T. wilfordii) Hook F. It exhibits potent antitumor, immunosuppressive, and anti-inflammatory biological activities; however, its clinical application is hindered by severe systemic toxicity.
View Article and Find Full Text PDFA lysosome-located and rhodamine-based fluorescence probe for recognizing hydrogen polysulfide.
J Pharm Biomed Anal
November 2024
School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, PR China.
Hydrogen polysulfide (HS, n≥2), as a kind of active sulfur species (RSS), has become a hot topic in RSS. It can regulate the biological activity of many proteins through S-sulfhydrylation of cysteine residues (protein Cys-SSH), and has a protective effect on cells. Although there have been some studies on hydrogen polysulfide, its production, degradation pathway and regulation mechanism still need further be researched.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!