[This corrects the article DOI: 10.1371/journal.pone.0151461.].
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957412 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197871 | PLOS |
Publication Analysis
Top Keywords
Similar Publications
The cellular and extracellular proteomic signature of human dopaminergic neurons carrying the LRRK2 G2019S mutation.
Front Neurosci
December 2024
German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
Background: Extracellular vesicles are easily accessible in various biofluids and allow the assessment of disease-related changes in the proteome. This has made them a promising target for biomarker studies, especially in the field of neurodegeneration where access to diseased tissue is very limited. Genetic variants in the LRRK2 gene have been linked to both familial and sporadic forms of Parkinson's disease.
View Article and Find Full Text PDFRevealing the Causes of Dyslexia through a Differential Diagnosis, a Short-Term Effective Treatment and an Appropriate Conceptual Framework.
Diagnostics (Basel)
September 2024
Institute for Social Pediatrics and Adolescent Medicine, Ludwig-Maximilians-University of Munich, Haydnstr. 5, D-80336 Munich, Germany.
Various different impairments and their interactions can cause reading problems referred to as "dyslexia". Since reading requires the interaction of many abilities, the impairment of each of these abilities can result in dyslexia. Therefore, the diagnosis must differentiate various kinds of dyslexia.
View Article and Find Full Text PDFField emission: calculations supporting a new methodology of comparing theory with experiment.
R Soc Open Sci
November 2022
Advanced Technology Institute & School of Computer Science and Electronic Engineering, University of Surrey, Guildford, Surrey GU2 7XH, UK.
This paper provides a demonstration-of-concept of a new methodology for comparing field electron emission (FE) theory and experiment. It uses the parameter in the mathematical equation = exp[-/ ] (where and are weakly varying or constants) that is taken to describe how measured current depends on measured voltage for electronically ideal FE systems (i.e.
View Article and Find Full Text PDFAn Experimentally Based Micromechanical Framework Exploring Effects of Void Shape on Macromechanical Properties.
Materials (Basel)
June 2022
Centre for ECO2 Vehicle Design, SE-100 44 Stockholm, Sweden.
A micromechanical simulation approach in a Multi-Scale Modeling (MSM) framework with the ability to consider manufacturing defects is proposed. The study includes a case study where the framework is implemented exploring a cross-ply laminate. The proposed framework highlights the importance of correct input regarding micromechanical geometry and void characteristics.
View Article and Find Full Text PDFIn Silico Structure-Based Approach for Group Efficiency Estimation in Fragment-Based Drug Design Using Evaluation of Fragment Contributions.
Molecules
March 2022
Department of Chemistry, Lomonosov Moscow State University, 119991 Moscow, Russia.
The notion of a contribution of a specific group in an organic molecule's property and/or activity is both common in our thinking and is still not strictly correct due to the inherent non-additivity of free energy with respect to molecular fragments composing a molecule. The fragment- based drug discovery (FBDD) approach has proven to be fruitful in addressing the above notions. The main difficulty of the FBDD, however, is in its reliance on the low throughput and expensive experimental means of determining the fragment-sized molecules binding.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!