A systematic study of axial strain effects on friction in carbon nanotube bearings is conducted in this paper. The relationships between friction and axial strains are determined by implementing molecular dynamics simulations. It is found that the dependence of friction on velocity and temperature is altered by axial strains. The mechanism of strain effects is revealed through numerical and theoretical analyses. Based on phonon computations, axial strain effects tune friction by adjusting the distribution of the phonon frequency density, which affects the transfer efficiency of orderly kinetic energy into disorderly thermal energy. The findings in this work advance the understanding of friction in carbon nanotubes and suggest the great potential of axial strain effects on tuning friction in nanodevice applications.
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http://dx.doi.org/10.1088/1361-6528/aac592 | DOI Listing |
Front Immunol
January 2025
Department of Bioengineering, College of Engineering, University of Toledo, Toledo, OH, United States.
Resolution of inflammation is essential for normal tissue healing and regeneration, with macrophages playing a key role in regulating this process through phenotypic changes from a pro-inflammatory to an anti-inflammatory state. Pharmacological and mechanical (mechanotherapy) techniques can be employed to polarize macrophages toward an anti-inflammatory phenotype, thereby diminishing inflammation. One clinically relevant pharmacological approach is the inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4).
View Article and Find Full Text PDFFront Immunol
January 2025
Department of Biomedicine, Aarhus University, Aarhus, Denmark.
The innate immune system plays a critical role in the rapid recognition and elimination of pathogens through pattern recognition receptors (PRRs). Among these PRRs are the C-type lectins (CTLs) langerin, mannan-binding lectin (MBL), and surfactant protein D (SP-D), which recognize carbohydrate patterns on pathogens. Each represents proteins from different compartments of the body and employs separate effector mechanisms.
View Article and Find Full Text PDFJ Marriage Fam
February 2025
Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, USA.
Objective: This study examines perceptions of changes in intimate relationships among partnered, immigrant women in New York City during the first year of the COVID-19 pandemic. We pay close attention to how structural oppression, particularly related to undocumented immigration status, shaped women's experiences with their intimate partners during a period of social upheaval.
Background: COVID-19 has exacerbated many existing structural inequities and subsequent stressors that have been shown to have an adverse effect on intimate relationships, including increased economic instability and mental health distress.
PeerJ
January 2025
Department of Dental Materials, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China.
Background: Periodontitis is not always satisfactorily treated with conventional scaling and root planing, and adjunctive use of antibiotics is required in clinical practice. Therefore, it is important for clinicians to understand the diversity and the antibiotic resistance of subgingival microbiota when exposed to different antibiotics.
Materials And Methods: In this study, subgingival plaques were collected from 10 periodontitis patients and 11 periodontally healthy volunteers, and their microbiota response to selective pressure of four antibiotics (amoxicillin, metronidazole, clindamycin, and tetracycline) were evaluated through 16S rRNA gene amplicon and metagenomic sequencing analysis.
Am J Prev Cardiol
December 2024
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Objectives: In observational studies, older adults with low serum vitamin D levels are at higher risk of cardiovascular disease (CVD), but randomized trials have failed to demonstrate reduction in CVD risk from vitamin D supplementation, possibly because the doses of vitamin D supplements tested were too low. Our objective was to determine if higher doses of vitamin D supplementation reduce high-sensitivity cardiac troponin (hs-cTnI) and N-terminal pro-b-type natriuretic peptide (NT-proBNP), markers of subclinical CVD.
Methods: The Study to Understand Fall Reduction and Vitamin D in You (STURDY) was a double-blind, randomized, response-adaptive trial that tested the effects of 4 doses of vitamin D3 supplementation (200, 1000, 2000, 4000 IU/day) on fall risk among older adults with low serum 25-hydroxyvitamin D concentrations (10-29 ng/mL).
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