The Public Health Agency of Canada (the Agency) has an important role to play in collaboration with its provincial/territorial partners to advance preparedness for emerging and re-emerging high-consequence infectious diseases. During the 2014 Ebola outbreak, the Agency established Ebola Virus Disease (EVD) Rapid Response Teams that were available to any requesting provincial/territorial jurisdiction with a laboratory confirmed case of EVD. Working with provincial and territorial officials, a Rapid Response Team Concept of Operations was developed which outlined the process for Rapid Response Team engagement as well as the suite of technical expertise available. The Concept of Operations was refined further following a series of face-to-face advance planning meetings with individual provincial and territorial jurisdictions. This led to a consensus agreement that the Agency's Rapid Response Team should be available to support management of both confirmed and suspected EVD cases. There was also unanimous support from provincial and territorial jurisdictions that the concept and operationalization of the Agency's Rapid Response Team should be broadened to provide surge-capacity support to the provinces and territories to include any event with significant public health consequences. The Agency will continue to engage with domestic and international partners regarding best practices to maintain a highly skilled and nimble Rapid Response Team that is operationally ready to support both domestic and international public health emergencies.
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http://dx.doi.org/10.14745/ccdr.v41is6a02 | DOI Listing |
Cell Commun Signal
January 2025
Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
One hallmark of cancer is the upregulation and dependency on glucose metabolism to fuel macromolecule biosynthesis and rapid proliferation. Despite significant pre-clinical effort to exploit this pathway, additional mechanistic insights are necessary to prioritize the diversity of metabolic adaptations upon acute loss of glucose metabolism. Here, we investigated a potent small molecule inhibitor to Class I glucose transporters, KL-11743, using glycolytic leukemia cell lines and patient-based model systems.
View Article and Find Full Text PDFScand J Trauma Resusc Emerg Med
January 2025
Department of Emergency Medicine and Pre-Hospital Services, St. Olav's University Hospital, Trondheim, Norway.
Background: First responders exist in several countries and have been a prehospital emergency medical resource in Norwegian municipalities since 2010. However, the Norwegian system has not yet been studied. The aim of this study was to describe the first responder system in Central Norway and how it is used as a supplement to emergency medical services (EMS).
View Article and Find Full Text PDFSci Rep
January 2025
Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, United States.
There are few in vitro models available to study microglial physiology in a homeostatic context. Recent approaches include the human induced pluripotent stem cell model, but these can be challenging for large-scale assays and may lead to batch variability. To advance our understanding of microglial biology while enabling scalability for high-throughput assays, we developed an inducible immortalized murine microglial cell line using a tetracycline expression system.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Electrical Engineering, College of Engineering, King Khalid University, P.O. Box 394, Abha, 61421, KSA, Saudi Arabia.
In wind energy generation systems, ensuring high energy quality is critical but is often compromised due to the limited performance and durability of conventional regulators. To address this, this work presents a novel controller for managing the machine-side inverter of a single-rotor large wind turbine system using an induction machine-type generator. The proposed controller is designed using proportional, integral, and derivative error-based mechanisms, which fundamentally differ from traditional proportional-integral (PI) regulators.
View Article and Find Full Text PDFNat Commun
January 2025
College of Chemistry, Nankai University, Tianjin, China.
Pathogenic intracellular bacteria pose a significant threat to global public health due to the barriers presented by host cells hindering the timely detection of hidden bacteria and the effective delivery of therapeutic agents. To address these challenges, we propose a tandem diagnosis-guided treatment paradigm. A supramolecular sensor array is developed for simple, rapid, accurate, and high-throughput identification of intracellular bacteria.
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