AI Article Synopsis
- Hyperpolarized MRI using [1-13C] pyruvate is a new technique that helps scientists study energy use in the brain and brain tumors.
- The first pictures from this method show how tumors change the way they produce energy differently from the normal brain.
- The findings suggest that this imaging method can help doctors see how well tumors are responding to treatments.
Article Abstract
Hyperpolarized (HP) MRI using [1-13C] pyruvate is a novel method that can characterize energy metabolism in the human brain and brain tumors. Here, we present the first dynamically acquired human brain HP 13C metabolic spectra and spatial metabolite maps in cases of both untreated and recurrent tumors. production of HP lactate from HP pyruvate by tumors was indicative of altered cancer metabolism, whereas production of HP lactate in the entire brain was likely due to baseline metabolism. We correlated our results with standard clinical brain MRI, MRI DCE perfusion, and in one case FDG PET/CT. Our results suggest that HP 13C pyruvate-to-lactate conversion may be a viable metabolic biomarker for assessing tumor response. Hyperpolarized pyruvate MRI enables metabolic imaging in the brain and can be a quantitative biomarker for active tumors. http://cancerres.aacrjournals.org/content/canres/78/14/3755/F1.large.jpg .
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6050093 | PMC |
| http://dx.doi.org/10.1158/0008-5472.CAN-18-0221 | DOI Listing |
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