AI Article Synopsis
- * The initial belief that MSCs replace damaged cells has shifted to understanding their "bystander" effect, where they secrete various growth factors and proteins that aid healing—known as the MSC secretome.
- * This review will explore current lab techniques to enhance the MSC secretome’s anti-inflammatory and regenerative properties, and assess its impact on recovery in stroke models.
Article Abstract
Mesenchymal stem cells (MSCs) hold great potential as a regenerative therapy for stroke, leading to increased repair and functional recovery in animal models of cerebral ischaemia. While it was initially hypothesised that cell replacement was an important mechanism of action of MSCs, focus has shifted to their paracrine actions or the so called "bystander" effect. MSCs secrete a wide array of growth factors, chemokines, cytokines and extracellular vesicles, commonly referred to as the MSC secretome. There is evidence suggesting the MSC secretome can promote repair through a number of mechanisms including preventing cell apoptosis, modulating the inflammatory response and promoting endogenous repair mechanisms such as angiogenesis and neurogenesis. In this review, we will discuss the in vitro approaches currently being employed to drive the MSC secretome towards a more anti-inflammatory and regenerative phenotype. We will then examine the role of the secretome in promoting repair and improving recovery in preclinical models of cerebral ischaemia.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077926 | PMC |
| http://dx.doi.org/10.1177/0271678X18776802 | DOI Listing |
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