AI Article Synopsis
- - This study investigates the differences in clinical features, molecular biomarkers, and prognostic outcomes between right-sided colon cancer (RCC) and left-sided colorectal cancer (LCRC) in Japanese patients, using data from 575 surgical cases between 2008 and 2011.
- - Results showed RCC patients tended to be older, predominantly female, and had advanced disease, while LCRC patients often presented with more venous invasion; molecular comparisons revealed unique biomarkers for each cancer type and distinct influences on prognosis.
- - The findings suggest that RCC has a poorer overall survival compared to LCRC, but other factors like age, gender, and specific mutations are more critical for prognosis than tumor location; additional research is needed to explore the unique characteristics of
Article Abstract
Background: The aim of this study was to clarify clinicopathological features, frequencies of molecular biomarkers, and prognoses in Japanese colorectal cancer patients and compare them with right-sided colon cancer (RCC) and left-sided colorectal cancer (LCRC).
Methods: We consecutively selected 575 colorectal cancer patients who underwent surgical resection from 2008 to 2011. RCC was located from the cecum to the transverse colon, and LCRC was located from the splenic flexure to the rectum. Frequencies of KRAS gene mutation, BRAF gene mutation, microsatellite instability (MSI), l18qLOH and CpG island methylator phenotype (CIMP) were statistically analyzed between groups.
Results: Tumors were located in the RCC in 26.3% of patients and in the LCRC in 73.7%. Elderly patients, females and advanced diseases were significantly more frequent in the RCC group than in the LCRC group. However, venous invasion was significantly more frequent in LCRC than in RCC. Between groups, BRAF mutant type, KRAS mutant type, MSI and CIMP+ were significantly more frequent in RCC, whereas 18qLOH was significantly more frequent in LCRC. In overall survival, RCC demonstrated poor prognosis compared with LCRC; however, age, gender, stage, lymphatic invasion, KRAS status and BRAF status rather than tumor location were independent prognostic factors. In addition, the independent prognostic factors in RCC were different from those in LCRC in each stage. However, the consistency between OS and DFS was not observed in this study, excluding lymphatic invasion in LCRC.
Conclusion: Comparing RCC with LCRC, RCC is different from LCRC in clinicopathological features, molecular biomarkers and prognostic factors in Japanese colorectal cancer patients. Since the proportions of molecular biomarkers of CRC in this study are different from Western CRCs, further studies are required to clarify the clinicopathological differences between Japanese CRCs and Western CRCs.
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| http://dx.doi.org/10.1093/jjco/hyy069 | DOI Listing |
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