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Challenging case of and in psoriatic patient treated with bimekizumab: The usefulness of mycological screening before biological therapies.
Med Mycol Case Rep
December 2024
Dermatology Unit, Department of Systems Medicine, University of Rome "Tor Vergata", 00133, Rome, Italy.
Psoriasis is a multifactorial immune-mediated disorder linked to the interleukin (IL)-17 signalling pathway. We present an unusual case of and caused by that developed after starting the IL-17A/F inhibitor bimekizumab. Our case underlines how psoriatic patients, treated with IL-17 inhibitors, should be screened for cutaneous fungal infections before and during treatment, in order to exclude a concomitant infection or the risk of its exacerbation.
View Article and Find Full Text PDFPrevalence of onychomycosis among psoriasis patients: a clinico-mycological and dermoscopic comparative cross sectional study.
Sci Rep
September 2024
Department of Dermatology, Venereology and Andrology, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt.
Article Synopsis
- * A study of 50 patients with psoriasis found that 22% tested positive for onychomycosis, with various fungi types identified among them, including dermatophytes and molds.
- * The research emphasizes the importance of combining mycology, histology, and dermoscopy for accurate diagnosis, revealing that spikes were the most common dermoscopic sign in onychomycosis cases while nail pitting was more typical of psoriasis.
Nailfold capillaroscopy for diagnosis of onychodystrophies: A prospective cross-sectional study.
J Am Acad Dermatol
January 2025
Department of Dermatology, Weill Cornell Medicine, New York, New York. Electronic address:
Article Synopsis
- Nail diseases pose significant physical and emotional challenges, but diagnosing them is difficult due to vague clinical signs, prompting the need for better diagnostic methods like nailfold capillaroscopy.
- This study aimed to analyze capillary changes in various nail conditions (like nail psoriasis and onychomycosis) and compare them to control groups based on demographic and clinical factors.
- Results indicated that specific nail conditions show distinct capillary patterns, suggesting that nailfold capillaroscopy could be a valuable, noninvasive tool to help diagnose and manage nail disorders more effectively.
Comparison of dermoscopic characteristics on toenail onychomycosis in psoriatic and non-psoriatic patients: A prospective study.
Mycoses
April 2024
Department of Dermatology, Peking University First Hospital, Beijing, China.
Article Synopsis
- Psoriatic patients often have onychomycosis (OM), but evaluating it in them is complicated due to possible differences from non-psoriatic cases.
- This study examined the dermoscopic features of toenail OM in 183 psoriatic patients compared to 232 non-psoriatic patients from 2020 to 2023, revealing significant differences in appearance.
- Results showed psoriatic toenail OM had more pitting and periungual telangiectasis, while non-psoriatic cases had features like nail spikes and yellow structureless areas, indicating distinct characteristics between the two groups.
A focused review on laser- and energy-assisted drug delivery for nail disorders.
Lasers Med Sci
January 2024
Albert Einstein College of Medicine, Montefiore Medical Center, 1300 Morris Park Ave, Bronx, NY, 10461, USA.
Article Synopsis
- This review examines laser-assisted drug delivery (LADD) methods for treating nail diseases, focusing on onychomycosis and psoriasis, based on a literature search conducted up to June 2023.
- It highlights the use of fractional ablative CO2 and Er:YAG lasers for enhancing the effectiveness of topical antifungal medications and treatments for psoriatic nails.
- The findings indicate that LADD is generally more effective than traditional topical treatments alone, although there are certain advantages and disadvantages to this newer approach that should be discussed between dermatologists and patients.
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