Objective: Neonatal sepsis is a major cause of morbidity and mortality of newborns (< 1 month of age). Septicemia and drug resistance is a predominant issue for neonatal death in Nepal. This study is intended to find bacteriological profile of neonatal sepsis and antibiotic susceptibility pattern of the isolates from neonates at Kanti Children's Hospital, Kathmandu, Nepal.
Results: Out of 350 suspected cases of neonatal sepsis, 59 (16.9%) cases showed positive blood culture. The prevalent of positive blood culture with different neonatal risk factors (sex, age, birth weight, gestational age, and delivery mode) showed highest positive bacterial growth in male (52.3%); 3 or above 3 days age (71.2%); low birth weight (62.7%); preterm gestational age (31.4%); and caesarean delivery mode (63.3%). Among positive cases, the bacteriological profile was found highest for Staphylococcus aureus (35.6%) followed by Klebsiella pneumoniae (15.3%). The most sensitive and resistive antibiotics among Gram-positive isolates were gentamicin (93%) and ampicillin (78%), respectively. Meropenem and imipenem showed highest 100% effective and cefotaxime was least (28%) sensitive among Gram-negative isolates. This concludes broad ranges of bacteria are associated with neonatal sepsis and revealed variation in antibiotic susceptibility pattern among bacterial isolates.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952417 | PMC |
| http://dx.doi.org/10.1186/s13104-018-3394-6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Autopsy-related histomorphological findings in neonatal sepsis: a narrative review.
Forensic Sci Med Pathol
January 2025
Centre for Foetal and Perinatal Pathology, Department of Pathology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Neonatal sepsis is an important concern in the field of neonatology, contributing significantly to morbidity and mortality among newborns worldwide. Despite progress in medical care, the accurate diagnosis and comprehension of the pathological underpinnings of neonatal sepsis continue to present challenges. Conventional diagnostic autopsy (CDA) provides unique opportunities to gain insights into the histomorphological alterations associated with neonatal sepsis.
View Article and Find Full Text PDF[High flow nasal cannula: is it a risk factor of bronchopulmonary dysplasia and retinopathy of premature?].
Andes Pediatr
August 2024
Servicio de Neonatologia, Complejo Asistencial Dr. Sótero del Río, Santiago, Chile.
Unlabelled: Observational studies have described an increase in the duration of oxygen therapy, bronchopulmonary dysplasia (BPD), and retinopathy of prematurity (ROP) in relation to the use of high-flow nasal cannula (HFNC, 2013-2016).
Objective: to analyze changes in the evolution of very preterm newborns with the use of HFNC.
Patients And Method: The incidence of neonatal pathologies between 2013 and 2021 was analyzed with a statistical process control.
Foals born alive from mares with ultrasonographically assessed placental abnormalities: Neonatal health and development up to weaning compared to foals from healthy mares.
Theriogenology
December 2024
Clinic for Horses - Unit for Reproductive Medicine, University of Veterinary Medicine, Hannover, Foundation, Buenteweg 15, 30559 Hanover, Germany; ReproTraining, Rolandstrasse 62, 33415 Verl, Germany. Electronic address:
Little is known about the health status of foals born alive from mares treated for placental disease. The aims of the present study were (1) to compare the neonatal health status and health development during the rearing period of foals born from mares treated for ultrasonographically assessed placental abnormalities (UPA) to age-matched healthy foals from the same warmblood stud and (2) analyze the influence of mare's placental health on colostrum quality. Foals (n = 127) born from mares with UPA (UPA group; P) in 2017-2019 were compared to 127 foals born from healthy mares (control group; C).
View Article and Find Full Text PDFIntroduction: Preterm birth (PTB) is associated with newborn morbidity and mortality. DNA methylation plays an important role in the development of fetus, thus can also serve as an epigenetic biomarker. Limited epigenetic studies were conducted in regard to PTB.
View Article and Find Full Text PDFNeonatal sepsis in Vietnam: Bacterial profiles and antibiotic susceptibility in a tertiary care setting.
Am J Infect Control
December 2024
Department of Microbiology, Vietnam National Children's Hospital, Hanoi, Vietnam.
Article Synopsis
- Neonatal sepsis is a major cause of newborn deaths in low and middle-income countries, prompting a study in Vietnam to analyze bacterial causes and antibiotic resistance patterns.
- A study at the National Children's Hospital identified 202 cases of sepsis, predominantly caused by Gram-negative bacteria, with Klebsiella pneumoniae as the most common pathogen.
- The research underscores the need for ongoing monitoring and specific antibiotic strategies to effectively address neonatal sepsis and its challenges.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!