AI Article Synopsis
- Myotonic dystrophy (MD) is a condition that affects muscles and the central nervous system, leading to symptoms like muscle weakness and excessive daytime sleepiness (EDS).
- In a case study of a 26-year-old female with MD type 1, it was found that EDS was linked to both sleep-related disorders and a central dysfunction in sleep regulation.
- Treatment with the medication agomelatine improved her sleep patterns and reduced sleepiness, highlighting the importance of identifying circadian rhythm disorders for effective treatment in patients with MD and EDS.
Article Abstract
Myotonic dystrophy (MD) is a neuromuscular disease with myotonia, progressive weakness, and involvement of CNS, heart, and gastrointestinal system. Excessive daytime sleepiness (EDS) in myotonic dystrophy type 1 (MD1) is related to sleep breathing diseases, restless leg syndrome, periodic limb movements during sleep and narcoleptic-like phenotype. However, authors highlight a central dysfunction of sleep regulation. We describe a 26-year-old, female, MD1 patient with EDS. Sleep diary/actigraphy evidenced two different circadian periods with values of 1442 and 1522 min. Agomelatine, 50 mg at night, was prescribed with improvement of the circadian rhythm and complaints of sleepiness. The identification of unanticipated causes of EDS, such as circadian rhythm disorders permits an appropriated treatment. As we know, it is the first relate of non-24-h sleep-wake disorder in patient with MD1. Sleep diary and actigraphy could be good options to investigate sleep-wake cycle disorder in patients with MD and EDS.
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| http://dx.doi.org/10.1080/07420528.2018.1471088 | DOI Listing |
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