Although tectorigenin (TG), a major compound in the rhizome of , is conventionally used for the treatment of inflammatory diseases, its effects on osteogenesis and osteoclastogenesis have not been reported. The objective of this study was to investigate the effects and possible underlying mechanism of TG on osteoblastic differentiation and bone formation, as well as osteoclast differentiation and bone resorption. TG promoted the osteogenic differentiation of primary osteoblasts and periodontal ligament cells. Moreover, TG upregulated the expression of the BMP2, BMP4, and Smad-4 genes, and enhanced the expression of Runx2 and Osterix. studies involving mouse calvarial bone defects with μCT and histologic analysis revealed that TG significantly increased new bone formation. Furthermore, TG treatment inhibited osteoclast differentiation and the mRNA levels of osteoclast markers. studies of mice demonstrated that TG caused the marked attenuation of bone resorption. These results collectively demonstrated that TG stimulated osteogenic differentiation , increased bone regeneration, inhibited osteoclast differentiation , and suppressed inflammatory bone loss . These novel findings suggest that TG may be useful for bone regeneration and treatment of bone diseases.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974624 | PMC |
| http://dx.doi.org/10.14348/molcells.2018.0056 | DOI Listing |
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