An 89-year-old woman presented with seizure and hyponatremia. CT and MRI demonstrated mass-like enlargement of the adrenal glands and multiple pulmonary nodules. PET/CT performed to evaluate for metastatic disease demonstrated intense F-FDG uptake within enlarged adrenal glands. Given mild uptake in the pulmonary nodules, the differential diagnosis for the adrenal uptake included lymphoma, granulomatous infection, and less likely, metastatic lung cancer.
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http://dx.doi.org/10.1097/RLU.0000000000002094 | DOI Listing |
BMC Pulm Med
March 2025
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, China.
Background: Pembrolizumab has been approved as a first-line treatment for non-small cell lung cancer (NSCLC) patients. However, a percentage of patients discontinue immunotherapy due to immune-related adverse events (irAE). Among these events, immune-related endocrine toxicities (E-irAE) represents the most common form, though their etiology, risk factors, and impact on patient outcomes remain poorly understood.
View Article and Find Full Text PDFBull Math Biol
March 2025
Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
The succinate dehydrogenase (SDH) is a four-subunit enzyme complex (SDH-a, SDH-b, SDH-c, and SDH-d) central to cell carbon metabolism. The SDH bridges the tricarboxylic acid cycle to the electron transport chain. A pathological loss of the SDH-b subunit leads to a cell-wide signalling cascade that shifts the cell's metabolism into a pseudo-hypoxic state akin to the so-called Warburg effect (or aerobic glycolysis).
View Article and Find Full Text PDFMedicine (Baltimore)
March 2025
Department of Surgery, College of Medicine, Majmaah University, Ministry of Education, AL-Majmaah City, Riyadh, Saudi Arabia.
Adrenal gland lacerations are sporadic but hostile injuries. The purpose of this investigation was to ascertain the prevalence, contributing variables, and outcomes of adrenal gland laceration in adult trauma victims. A retrospective cohort study analyzed data from 649,696 adult patients in the National Trauma Data Bank to compare patient characteristics, injury severity, and outcomes between patients with and without adrenal gland injuries.
View Article and Find Full Text PDFClin Nucl Med
March 2025
Department of Urology, Xiangya Hospital.
68Ga-pentixafor PET/CT is a reliable, noninvasive functional imaging technique that demonstrates high classification accuracy for subtypes of primary hyperaldosteronism (PA) and provides significant guidance for clinical treatment decisions. We report a case of the precise resection of an aldosterone-producing adenoma (APA) while maximizing the preservation of adrenal glands under the guidance of 68Ga-pentixafor PET/CT imaging.
View Article and Find Full Text PDFIndian J Nucl Med
January 2025
Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Differentiated thyroid carcinoma (DTC) metastasizing to the adrenal glands is very infrequent. We present three cases of DTC with adrenal metastasis in their follow-up, in which two were from follicular thyroid carcinoma and one from papillary thyroid carcinoma along with review of literature to emphasize the role of cross-sectional and correlative imaging in DTC with adrenal metastasis.
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