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Background: Members of the Fire Department of New York (FDNY) who responded to the World Trade Center (WTC) attacks that occurred on 9/11/2001 were exposed to severe trauma. The present study screened for cognitive impairment in a prospective cohort study of FDNY fire fighters and emergency personnel who reside in the greater NYC metropolitan area.
Method: A large sample (n = 338) of FDNY personnel who were exposed to the WTC attacks were recruited to complete a large battery of neuropsychiatric and psychological tests.
Background: The goal of this study was to determine the incidence of dementia before age 65 years in a prospective study of WTC responders, and compare incidence among responders with severe exposures to debris versus responders not exposed to building debris or those who wore personalized protective equipment (PPE).
Methods: Data were collected in a congressionally mandated academic occupation-based medical monitoring program available to all verified WTC-exposed responders residing on Long Island, NY, most of whom are currently <65 years of age. WTC responders aged ≤60 years without dementia at the time of their first cognitive assessment were followed every 18 months on average, for up to five years.
Background: World Trade Center (WTC) responders endured exposures to neurotoxic dust particulate matter. This neuroimaging study examined the presence of amyloidosis in Alzheimer's disease (AD) regions of interest (ROIs) and associations with exposure duration.
Method: Simultaneous positron-emission tomography with [F]-florbetaben and magnetic resonance neuroimaging was acquired on 34 middle aged WTC responders.
Alzheimer's Imaging Consortium.
Alzheimers Dement
December 2024
Stony Brook University, Stony Brook, NY, USA.
Background: World Trade Center (WTC) responders endured exposures to neurotoxic dust particulate matter. This neuroimaging study examined the presence of amyloidosis in Alzheimer's disease (AD) regions of interest (ROIs) and associations with exposure duration.
Method: Simultaneous positron-emission tomography with [18F]-florbetaben and magnetic resonance neuroimaging was acquired on 34 middle aged WTC responders.
Plasticity of human resilience mechanisms.
Sci Adv
January 2025
Normandie Univ, UNICAEN, PSL Research University, EPHE, INSERM, U1077, CHU de Caen, GIP Cyceron, Neuropsychologie et Imagerie de la Mémoire Humaine, 14000 Caen, France.
The hippocampus's vulnerability to trauma-induced stress can lead to pathophysiological disturbances that precipitate the development of posttraumatic stress disorder (PTSD). The mechanisms of resilience that foster remission and mitigate the adverse effects of stress remain unknown. We analyzed the evolution of hippocampal morphology between 2016/2017 and 2018/2019, as well as the memory control mechanisms crucial for trauma resilience.
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