AI Article Synopsis
- * It was found that 54% of patients had an elevated LGI1-IgG index indicative of intrathecal synthesis, and those with higher indices typically had worse outcomes according to the modified Rankin Scale.
- * Additionally, higher levels of the LGI1-IgG4 subclass were associated with worse patient outcomes, suggesting that monitoring these levels could guide the need for aggressive immunotherapy.
Article Abstract
To determine whether CSF leucine-rich glioma-inactivated 1(LGI1)-IgG titer, index or IgG subclass has prognostic significance, we tested serum and CSF specimens collected concomitantly from 39 seropositive patients. LGI1-IgG index was elevated (>1) in 21 patients (54%), suggesting intrathecal synthesis. Patients with worse outcome at last follow-up (modified Rankin Scale >2) had significantly higher index (median 6.57 vs. 0.5, = 0.048) compared to those with better outcome. Higher CSF LGI1-IgG4 subclass-specific titer and index correlated with worse outcome ( < 0.005 for both). These data suggest that evidence of intrathecal LGI1-IgG synthesis may correlate with neuronal injury and warrant consideration of aggressive immunotherapy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945965 | PMC |
| http://dx.doi.org/10.1002/acn3.561 | DOI Listing |
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