AI Article Synopsis
- Atherosclerosis is the main cause of cardiovascular diseases, and inflammation plays a key role in its development.
- Human gingiva-derived mesenchymal stem cells (GMSC) have shown promise in reducing inflammation and may influence atherosclerosis, which is not well understood.
- This study found that GMSC infusion reduced inflammatory macrophages, plaque size, and lipid deposits in AopE mice, highlighting their potential in regulating inflammation and combating atherosclerosis.
Article Abstract
Atherosclerosis is the major cause of cardiovascular diseases. Current evidences indicate that inflammation is involved in the pathogenesis of atherosclerosis. Human gingiva-derived mesenchymal stem cells (GMSC) have shown anti-inflammatory and immunomodulatory effects on autoimmune and inflammatory diseases. However, the function of GMSC in controlling atherosclerosis is far from clear. The present study is aimed to elucidate the role of GMSC in atherosclerosis, examining the inhibition of GMSC on macrophage foam cell formation, and further determining whether GMSC could affect the polarization and activation of macrophages under different conditions. The results show that infusion of GMSC to AopE mice significantly reduced the frequency of inflammatory monocytes/macrophages and decreased the plaque size and lipid deposition. Additionally, GMSC treatment markedly inhibited macrophage foam cell formation and reduced inflammatory macrophage activation, converting inflammatory macrophages to anti-inflammatory macrophages . Thus, our study has revealed a significant role of GMSC on modulating inflammatory monocytes/macrophages and alleviating atherosclerosis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937358 | PMC |
| http://dx.doi.org/10.3389/fimmu.2018.00878 | DOI Listing |
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