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Label-free sensitive luminescence biosensor for immunoglobulin G based on AgAu ethisterone cluster-estrogen receptor α aggregation and graphene. | LitMetric

Label-free sensitive luminescence biosensor for immunoglobulin G based on AgAu ethisterone cluster-estrogen receptor α aggregation and graphene.

Talanta

MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, China.

Published: August 2018

AI Article Synopsis

Article Abstract

A specific and label-free "on-off-on" luminescence biosensor based on a novel heterometallic cluster [AgAu(ethisterone)]-estrogen receptor α (AgAuEth-ERα) aggregation utilizing graphene oxide (GO) as a quencher to lead a small background signal was firstly constructed to detect immunoglobulin G (IgG) with a simple process and high selectivity. The efficient photoluminescent (PL) AgAuEth-ERα aggregation is strongly quenched by GO. In the presence of IgG, the PL of this system will be restored, and perceivable by human eyes under UV lamp excitation (365 nm). The quenching mechanism of GO on AgAuEth-ERα and enhancement mechanism of IgG on AgAuEth-ERα-GO were investigated in detail. Under the optimum conditions, the biosensor for high sensitive IgG detection expressed a wider linear range of 0.0078-10 ng/mL and a lower detection limit of 0.65 pg/mL with good stability and repeatability, which provided a new approach for label-free IgG detection.

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Source
http://dx.doi.org/10.1016/j.talanta.2018.03.075DOI Listing

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