Gout and pseudogout are crystalline arthropathies commonly seen in primary care. It is important to understand their pathophysiology to facilitate recognition and appropriate treatment. Prompt gouty arthritis treatment relieves short-term suffering. Long-term treatment with urate-lowering therapy prevents recurrent attacks and is generally well-tolerated though flare risk is increased during treatment initiation. When anti-inflammatory medications are prescribed, the flare risk is low. Pseudogout acute treatment is similar to acute gouty arthritis treatment. There is no standard regimen for long-term chronic therapies of pseudogout. This article enhances the recognition and treatment of these diseases in the primary care setting.
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