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An economic model to value companion diagnostics in non-small-cell lung cancer. | LitMetric

An economic model to value companion diagnostics in non-small-cell lung cancer.

Per Med

Jefferson School of Population Health, Thomas Jefferson University, 1015 Walnut St Suite 115, Philadelphia, PA 19107, USA.

Published: March 2013

AI Article Synopsis

Article Abstract

Aim: An economic model was used to evaluate the potential economic impact and cost-effectiveness of companion diagnostic testing for patients with non-small-cell lung cancer (NSCLC).

Materials & Methods: A decision analysis model examined alternative patient management strategies for patients with advanced NSCLC who were not amenable to surgical treatment. A review of the literature provided the variables used to develop a timely base case and sensitivity analysis. A potential future scenario was also modeled. The model includes three options: conventional treatment (CT), new treatment (NT) and companion diagnostic (CD) strategy.

Results: In the base case analysis based upon current data, the cost per life-year saved for CT, NT option and CD was US$43,367, US$47,394 and US$47,779, respectively. The cost per life-year saved for CT, NT option and CD in a potential future scenario with more expensive, effective targeted therapy was US$47,748, US$69,255 and US$66,369, respectively.

Conclusion: In the future scenario, CDs have an incremental cost-effectiveness of US$56,829 per life-year saved when compared with NT as a first-line treatment. This is one demonstration of how CDs may be a cost-effective option for the treatment of patients with advanced NSCLC when the NT is extremely expensive but the outcome is significantly improved.

Download full-text PDF

Source
http://dx.doi.org/10.2217/pme.13.7DOI Listing

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