The purpose of this review is to discuss immunologic tolerance as it applies to solid organ transplantation and to identify barriers that hinder the achievement of this long-term goal. First, the definition of tolerance and an introduction of mechanisms by which tolerance exists or can be achieved will be discussed. Next, a review of contemporary attempts at achieving transplant tolerance will be described. Finally, a discussion of the humoral barriers to transplantation tolerance and potential ways to overcome these barriers will be presented.
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http://dx.doi.org/10.1097/TP.0000000000002242 | DOI Listing |
Transpl Infect Dis
January 2025
Department of Infectious Diseases, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, Brazil.
Background: Cytomegalovirus (CMV) infection remains among the leading complications after solid organ transplantation (SOT). Large international surveys mainly focused on high-income countries, detected considerable variability in the management of this infection after SOT. Limited data are available from resource-limited settings.
View Article and Find Full Text PDFCurr Opin Organ Transplant
January 2025
Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Purpose Of Review: The epidemiologic phenomenon known as the "Hispanic paradox" postulates that Hispanic/Latino Americans generally tend to live longer than other racial/ethnic communities, despite facing many socioeconomic disadvantages and other healthcare barriers. Whether this phenomenon is relevant among kidney transplantation (KT) recipients remains unclear. To investigate the possibility of a Hispanic mortality advantage, we conducted a systematic review of the published literature comparing short-term KT outcomes (first 12-months) for US Hispanic versus non-Hispanic White KT recipients.
View Article and Find Full Text PDFMol Nutr Food Res
January 2025
College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi, China.
Fecal microbiota transplantation (FMT) could significantly alter the recipient's gut bacteria composition and attenuate obesity and obesity-related metabolic syndromes. DL-norvaline is a nonproteinogenic amino acid and possesses anti-obesity potential. However, the specific mechanisms by which gut microbiota might mediate beneficial effects of DL-norvaline have not been completely elucidated.
View Article and Find Full Text PDFAnn Thorac Surg Short Rep
December 2024
Toronto Lung Transplant Program, Toronto General Hospital, Toronto, Canada.
Ex vivo lung perfusion (EVLP) is used to evaluate donor lungs prior to lung transplantation. Development of pulmonary edema during EVLP is generally thought to represent inflammatory breakdown of the air-fluid barrier and these lungs are declined for transplant. We present the case of a donor lung that underwent stapled wedge resection during cold storage for air leak and the subsequent development of profound (∼650 mL) pulmonary edema around the staple line during EVLP.
View Article and Find Full Text PDFJ Gen Intern Med
January 2025
Department of Medicine, University of Colorado, Aurora, CO, USA.
Background: Undocumented individuals with hematologic malignancies in the United States face barriers to receiving often-curative stem cell transplant (SCT), instead receiving inferior treatment with higher mortality. Federal and state policies' impact on undocumented individuals' lived experiences goes unnoticed.
Objective: To understand the experiences of this rare population of undocumented individuals with hematologic malignancies who cannot receive medically indicated SCT.
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