Protactinium-230 ( t = 17.4 d) is the parent isotope of U ( t = 20.8 d), a radionuclide of interest for targeted alpha therapy (TAT). Column chromatographic methods have been developed to separate no-carrier-added Pa from proton irradiated thorium targets and accompanying fission products. Results reported within demonstrate the use of novel sulfur bearing chromatographic extraction resins for the selective separation of protactinium. The recovery yield of Pa was 93 ± 4% employing a RP═S type commercially available resin and 88 ± 4% employing a DGTA (diglycothioamide) containing custom synthesized extraction chromatographic resin. The radiochemical purity of the recovered Pa was measured via high purity germanium γ-ray spectroscopy to be >99.5% with the remaining radioactive contaminant being Nb due to its similar chemistry to protactinium. Measured equilibrium distribution coefficients for protactinium, thorium, uranium, niobium, radium, and actinium on both the RP═S type and the DGTA resin in hydrochloric acid media are reported, to the best of our knowledge, for the first time.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.analchem.8b01380 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Simultaneous Separation of Protactinium-230 and Uranium-230 Isotopes from a Proton-Irradiated Thorium Matrix.
Anal Chem
April 2024
Radioisotope Science and Technology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States.
The use of radioisotopes in cancer therapy is becoming increasingly important. As a potential candidate for targeted alpha therapy, U ( = 20.8 d), the decay daughter of Pa ( = 17.
View Article and Find Full Text PDFSeparation of protactinium from uranium-niobium alloys for Pa-U radiochronometry in nuclear forensic investigations.
J Radioanal Nucl Chem
May 2023
Nuclear and Radiochemistry Group, Chemistry Division, Los Alamos National Laboratory, Los Alamos, NM 87545 USA.
Unlabelled: The isolation and purification of protactinium from uranium materials is essential for Pa-U radiochronometry, but separating Pa from uranium-niobium alloys, a common material in the nuclear fuel cycle, is challenging due to the chemical similarity of Pa and Nb. Here we present three resin chromatography separation techniques for isolating Pa from U and Nb which were independently developed by three different laboratories through ad hoc adaptations of standard operating procedures. Our results underscore the need for and value of purification methods suitable for a diversity of uranium-based materials to ensure the operational readiness of nuclear forensics laboratories.
View Article and Find Full Text PDFProduction of Pa by proton irradiation of Th at the LANL isotope production facility: Precursor of U for targeted alpha therapy.
Appl Radiat Isot
February 2020
Chemistry Division, Los Alamos National Laboratory, P.O. Box 1663, Los Alamos, NM, 87545, USA. Electronic address:
Uranium-230 (t = 20.8 d) is an alpha-emitting radionuclide that has potential application in targeted alpha therapy (TAT) of cancer. Its parent isotope Pa (t = 17.
View Article and Find Full Text PDFSeparation of Protactinium Employing Sulfur-Based Extraction Chromatographic Resins.
Anal Chem
June 2018
Chemistry Division , Los Alamos National Laboratory , P.O. Box 1663, Los Alamos , New Mexico 87545 , United States.
Protactinium-230 ( t = 17.4 d) is the parent isotope of U ( t = 20.8 d), a radionuclide of interest for targeted alpha therapy (TAT).
View Article and Find Full Text PDFImproved Separation of Pa from Th and U in Marine Sediments with TK400 Resin.
Anal Chem
January 2018
TrisKem International, 3 rue des champs Geons, 35170 Bruz, France.
Protactinium-231 is a radionuclide of broad interest in paleoceanography and paleoclimatology. This study describes an improved method for the purification and separation of Pa from marine sediment samples using the new TK400 resin by TrisKem International. The focus lies on the improvement of the separation of the abundant Th from the Pa fraction of the sample, which would reduce the peak tailing from Th on masses 231 and 233 during ICP-MS measurement.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!