Fine particulate matter associated mortality burden of lung cancer in Hebei Province, China.

Background: The association between fine particulate matter (PM ) and lung cancer (LC) mortality in China is limited. The Beijing-Tianjin-Hebei region is infamous for serious air pollution. Seven of the top 10 cities with the worst air quality are located in Hebei Province. Thus, we explored the effect of 10 years of PM on the LC mortality rate in Hebei Province.

Methods: We quantified associations between LC mortality and PM and estimated the LC mortality burden attributed to PM with predicted county level LC deaths in 2014.

Results: The 10-year PM LC mortality associations were non-linear, with thresholds of 63 μg/m overall, 69 μg/m for men, 68 μg/m for women, 66 μg/m for those aged 30-64 years, and 62 μg/m for those aged ≥ 65 years. The relative risks for these groups were 1.09 (95% confidence interval [CI] 1.08-1.10), 1.06 (95% CI 1.03-1.10), 1.20 (95% CI 1.10-1.26), 1.07 (95% CI 1.05-1.11), and 1.10 (95% CI: 1.07-1.13), respectively. There were 2525 (95% CI 2265-2780) LC deaths attributed to 10-year PM in 2014, at fractions of 8.3% (95% CI 7.4-9.1%) overall, 5.7% (95% CI 2.8-9.4%) for men, 16.7% (95% CI: 8.3-21.6%) for women, 6.5% (95% CI 4.7-10.3%) for those aged 30-64 years, and 9.1% (95% CI 6.4-11.5%) for those aged ≥ 65 years.

Conclusion: Our results suggest that a reduction in the PM exposure levels below thresholds would prevent a substantial number of LC deaths in Hebei Province.