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Introduction And Importance: Retiform hemangioendothelioma(RH) is a rare vascular tumor affecting patients over a wide age range without a gender predilection; only about 50 cases have been described so far.

Case Presentation: We report a case of submandibular retiform hemangioendothelioma in a 58-year-old woman who had been diagnosed with RH 20 years ago and had experienced recurrence four times during the past 20 years. This will increase the limited number of such cases in the hope of gaining a better understanding of this rare type of tumor.

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Composite hemangioendothelioma comprises permutations of different histological patterns few of which have been found to have specific genetic alteration and immunohistochemical expression. It comprises retiform or epithelioid hemangioendothelioma-like areas, with a variable proportion of hemangioma or low-grade angiosarcoma-like areas. It was found to express neuroendocrine markers and was seen to have a worse prognosis in recurrence or distant metastasis.

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Targetoid hemosiderotic hemangioma: A review article.

Semin Diagn Pathol

November 2024

University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216, United States. Electronic address:

Article Synopsis
  • Targetoid hemosiderotic hemangioma (THH) is a rare vascular lesion that mainly affects adults, usually developing after trauma, with no significant gender preference.
  • The review analyzes THH's characteristics, differentiating it from similar conditions like Kaposi's sarcoma and retiform hemangioendothelioma.
  • Clinically, THH appears as painless lesions with a distinctive target-like look; histologically, it shows specific vascular features and can be identified with immunohistochemical markers.
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Introduction: Vascular malignancies are categorized into benign hemangiomas, malignant angiosarcomas, and tumors of intermediate malignancy. Retiform hemangioendothelioma (RH) is one of the rare diagnoses belonging to the class of intermediate malignancies that was initially diagnosed.

Case Presentation: In this case report, we have reported a rare case of RH, a locally aggressive, vascular tumor of malignant potential presenting at an unusual site.

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