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A high throughput assay for phosphoribosylformylglycinamidine synthase.
SLAS Discov
January 2025
The Hormel Institute, University of Minnesota, Austin, MN 55912. Electronic address:
Metabolic reprogramming of purine biosynthesis is a hallmark of cancer metabolism and represents a critical vulnerability. The enzyme phosphoribosylformylglycinamidine synthase (PFAS) catalyzes the fourth step in de novo purine biosynthesis and has been demonstrated to be prognostic for survival of liver cancer. Despite the importance of this protein as a drug target, there are no known specific inhibitors of PFAS activity.
View Article and Find Full Text PDFCarbon nitride grafted with single-atom manganese and 2-hydroxy-4,6-dimethylpyrimidine: A visible-light-driven photocatalyst for enhanced ozonation of organic pollutants.
J Colloid Interface Sci
December 2024
State Key Laboratory of Photocatalysis On Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou 350108, PR China. Electronic address:
The development of durable and highly efficient visible-light-driven photocatalysts is essential for the photocatalytic ozonation process towards degrading organic pollutants. This study presents CN-MA, a novel photocatalyst synthesized by grafting carbon nitride (CN) with single-atom Mn and 2-hydroxy-4,6-dimethylpyrimidine (HDMP) via one-step thermal polymerization. Experimental characterization and theoretical calculation results reveal that incorporating single-atom Mn and HDMP into CN alters the charge density distribution on the heptazine rings.
View Article and Find Full Text PDFMechanism-based Modelling for Fitting the Double-exponential Progress Curves of Cellulase Reaction.
J Appl Glycosci (1999)
November 2024
1 Department of Biomaterial Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo.
Enzymatic hydrolysis of cellulosic biomass is a complex process involving many factors, including multiple enzymes, heterogeneous substrates, and multi-step enzyme reactions. Cellulase researchers have conventionally used a double-exponential equation to fit the experimental time course of product formation, but no theoretical basis for this has been established. Here we present a mechanism-based equation that fits well the progress curves of cellulase reaction, incorporating the concepts of non-productive and productive binding on the cellulose surface and processivity.
View Article and Find Full Text PDFBiomarker detection based on nanoparticle-induced ultrasonic Rayleigh scattering.
Microsyst Nanoeng
December 2024
Key Laboratory of Optoelectronic Technology and Systems, Ministry of Education and International Research and Development Center of Micro-Nano Systems and New Materials Technology, Chongqing University, Chongqing, 400044, China.
Article Synopsis
- Ultrasonic biochemical detection is crucial for identifying biomarkers and monitoring drugs, but current methods are expensive and unreliable, making them unsuitable for low-cost rapid testing.
- This study introduces a new detection mechanism using Rayleigh scattering from nanoparticles, which alters sound pressure and enhances measurement reliability by modifying antibodies on a separate substrate.
- Results show that using a CMUT chip, the detection of CA19-9 cancer antigen is successful across various concentrations, while minimizing interference from other markers, proving the effectiveness of this approach.
Bioinspired Microhinged Actuators for Active Mechanism-Based Metamaterials.
Adv Sci (Weinh)
January 2025
Department of Advanced Manufacturing and Robotics, State Key Laboratory for Turbulence and Complex Systems, BIC-ESAT, College of Engineering, Peking University, Beijing, 100871, China.
Mechanism-based metamaterials, comprising rigid elements interconnected by flexible hinges, possess the potential to develop intelligent micromachines with programmable motility and morphology. However, the absence of efficient microactuators has constrained the ability to achieve multimodal locomotion and active shape-morphing behaviors at the micro and nanoscale. In this study, inspiration from the flight mechanisms of tiny insects is drawn to develop a biomimetic microhinged actuator by integrating compliant mechanisms with soft hydrogel muscle.
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