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Hippocampal 5-HT Input Regulates Memory Formation and Schaffer Collateral Excitation. | LitMetric

AI Article Synopsis

  • The study investigates the role of serotonin (5-HT) in memory storage, particularly in the mammalian hippocampus, which is less understood compared to its role in the invertebrate Aplysia.
  • Using optogenetic techniques on mice, researchers found that activating serotonergic terminals in the hippocampal CA1 region improves spatial memory and enhances synaptic transmission.
  • The findings highlight the importance of 5-HT4 receptors in this process, suggesting that manipulating these receptors can affect memory formation both positively and negatively.

Article Abstract

The efficacy and duration of memory storage is regulated by neuromodulatory transmitter actions. While the modulatory transmitter serotonin (5-HT) plays an important role in implicit forms of memory in the invertebrate Aplysia, its function in explicit memory mediated by the mammalian hippocampus is less clear. Specifically, the consequences elicited by the spatio-temporal gradient of endogenous 5-HT release are not known. Here we applied optogenetic techniques in mice to gain insight into this fundamental biological process. We find that activation of serotonergic terminals in the hippocampal CA1 region both potentiates excitatory transmission at CA3-to-CA1 synapses and enhances spatial memory. Conversely, optogenetic silencing of CA1 5-HT terminals inhibits spatial memory. We furthermore find that synaptic potentiation is mediated by 5-HT4 receptors and that systemic modulation of 5-HT4 receptor function can bidirectionally impact memory formation. Collectively, these data reveal powerful modulatory influence of serotonergic synaptic input on hippocampal function and memory formation.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383566PMC
http://dx.doi.org/10.1016/j.neuron.2018.04.030DOI Listing

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